Szilard Voros

Szilard Voros
Born	Budapest, Hungary
Education	University of Alabama at Birmingham (Residency), University Medical School of Pécs (M.D.)
Occupation	Cardiologist, Scientist

Szilard Voros is a Hungarian-born American cardiologist and globally renowned leading research scientist in advanced cardiovascular imaging, biomarkers, lipoprotein metabolism and genomics. He currently serves as an Associate Professor of Medicine/Cardiology and Radiology, and Director of Advanced Cardiovascular MR and CT Research at the Department of Radiology and Cardiology at Stony Brook University Medical Center, State University of New York. He previously served as the Chief Scientific Officer, Chief of Cardiovascular Prevention, and Medical Director of Cardiac MR and CT at Piedmont Hospital in Atlanta, Georgia, and as a Clinical Associate Professor of Medicine at the Medical College of Georgia. He is a founding member and Fellow of the Society of Cardiovascular Computed Tomography (FSCCT), Fellow of the American College of Cardiology (FACC) and Fellow of the American Heart Association (FAHA).

Biography

In 1996, as a Summa Cum Laude graduate of the University Medical School of Pécs in Hungary, Dr. Voros moved to the United States to pursue his Internship and Residency in Internal Medicine at the University of Alabama at Birmingham from 1997 to 2000. In 2000,he was invited to serve as Clinical Instructor in Medicine and Chief Medical Resident at the University of Alabama at Birmingham.^[1] While at UAB, Dr. Voros was inspired to pursue cardiology and non-invasive cardiovascular imaging.Under the mentorship of Dr. Navin Nanda and Dr. Gerald Pohost, both globally renowned expert cardiologists and scientists in their respective specialties, Dr. Voros furthered his interest in cardiovascular imaging. As he would later discover, this interest would become his passion. Dr. Voros was one of the first handful of physicians globally, who were Level III trained in Cardiovascular Magnetic Resonance Imaging and Computed Tomography.

In 2008, Fox 7 News aired a Health Edge special on The Family Heart Disease Program, a Voros led initiative that identified family members at high risk of developing coronary artery disease and educated them on how to reduce the risks for themselves and their families.^[2][3]

Most recently, Voros was interviewed on Fox 5 News for a Health Watch special on the Corus CAD test,a blood-based test that measures the expression levels of 23 genes that have demonstrated to indicate obstructive coronary artery disease (CAD).^[4]

Dr. Voros has published extensively in the field of advanced cardiovascular imaging. He regularly lectures at national and international meetings, including many prestigious conferences sponsored by the American College of Cardiology.^[5] Working with CardioDx, Inc (Palo Alto, CA), he recently published a paper in the Annals of Internal Medicine describing the first genomic blood-based diagnostic test for the detection of significant blockages in the heart.^[6] Dr. Voros is independently funded to do important clinical research on advanced cardiovascular imaging, atherosclerosis and lipoprotein abnormalities. Dr. Voros and his team recently completed the ATLANTA I and ATLANTA II studies, which focused on assessing the morphology and other characteristics of blockages in the heart using heart catheterization, cardiac CT, intravascular ultrasound, and near infrared spectroscopy.

In 2010, Voros and his team published an article on their advanced method of coronary artery calcium quantification, the Lesion Specific Calcium Score. This method has been shown, through research, to be superior to the Agatston Score.

Publications

Garan H, Voros S: Cardiac Arrhythmias. Chapter 65. Imaging in Cardiovascular Disease. Editors: G. Pohost, R. O'Rourke, P. Shah, D. Berman.

Voros S. Electrophysiologic Disorders. Editors: G. Pohost, K. Nayak. Informa Healthcare 2006.

Voros S, Nanda NC, Thakur AC, Narayan VK, Samal AK: Lambl's Excrescences Involving the Pulmonary Valve Detected by Transesophageal Echocardiography. Echocardiography, 1999(16):35-39.

Thakur AC, Voros S, Nanda NC, Gomez CR, Terry JB, Tulyapronchote R, Ocako: Transesophageal Echocardiographic Diagnosis of Proximal Coronary Artery Stenosis in Patients with Ischemic Stroke. Echocardiography, 1999(16):159-165.

Nanda NC, Thakur AC, Thakur D, Narayan VK, Espinal MA, Shoeb G, Samal AK, Voros S, Aaluri SR, Ocak O, John AS, Pasia AT, Aikens M.Transesophageal echocardiographic examination of left subclavian artery branches. Echocardiography, 1999(16):271-277.

Voros S, Nanda NC, Thakur AC, Winokur TS, Samal AK: Lambl's excrescences (Valvular Strands). Echocardiography, 1999(16):399-413.

Samal AK, Nanda NC, Thakur AC, Narayan VK, Ocak O, Lee TY, Voros S, Jindal A, Winokur TS. Three-Dimensional Echocardiographic Assessment of Lambl's Excrescences on the Aortic Valve. Echocardiography, 1999(16):437-441.

Voros S, Nanda NC. Transesophageal Echocardiographic Assessment of Proximal Coronary Artery Stenosis in Elderly Patients with Ischemic Stroke. Am J Geriatric Cardiology, 2000;9(4):197-203.

Biederman RWW, Sorrell VL, Nanda NC, Voros S, Thakur AC. Transesophageal Echocardiographic Assessment of Coronary Stenosis: A Decade of Experience. Echocardiography, 2001;18(1):49-57.

Voros S, Nanda NC, Samal AK, Gomez CR, Puri VK, Jindal A, Terry JB, Tulyapronchote R, Thakur AC. Transesophageal Echocardiography Performed in Stroke Patients to Exclude Cardiac Sources of Embolism Accurately Detects Significant Proximal Coronary Artery Stenosis and Often Changes Management. American Heart Journal 2001;142:916-922.

Voros S, Kramer CM. Clinical applications of cardiovascular magnetic resonance imaging. Heartwise 2003;6(4):4-10.

Keser N, Nanda NC, Miller AP, Voros S, Soydas C, Agrawal G, Liguori C, Naftel D, Pacifico AD, Kirklin JK, McGiffin DC, Holman WL. Hemodynamic Evaluation of Normally Functioning Sulzer Carbomedics Prosthetic Valves. Ultrasound Med Biol. 2003 May;29(5):649-57.

Patel RAG, Dimarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. J Cardiovasc Magn Reson, 2005;7:685-688.

Voros S, Kramer CM. "Cardiovascular MRI: State of the Art" in Clinical Cardiology Reviews, (Bentham Science Publishers, London) 2005;1:181-188.

Szilard Voros MD, Zequan Yang MD, PhD, Christina M. Bove MD, Wesley D. Gilson PhD, Frederick H. Epstein PhD, Brent A. French, PhD, Stuart S. Berr PhD, Sanford P. Bishop PhD, DVM, Hiroaki Matsubara MD, PhD, Robert M. Carey MD, Christopher M. Kramer MD, FACC. The AT2 Receptor Mediates Most of the Benefit of AT1 Receptor Blockade During Post-Infarction Left Ventricular Remodeling. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1004-10. Epub 2005 Oct 7.

Bove CM, DiMaria JM, Voros S, Conaway MR, Kramer CM. Dobutamine Response and Myocardial Infarct Transmurality: Functional Improvement after Coronary ArteryBypass Grafting—Initial Experience. Radiology 2006;240(3):835-842.

Akram K, Silverman ME, Voros S. A Unique Case of Pulmonary Artery Leiomyosarcoma. J Natl Med Assoc. 2006;98(12):1995-96.

Interaction Between Bradykinin Subtype 2 and Angiotensin II Type 2 Receptors During Post-MI Left Ventricular Remodeling. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3372-8. Isbell DC, Voros S, Yang Z, DiMaria JM, Berr SS, French BA, Epstein FH, Bishop SP, Wang H, Roy RJ, Kemp BA, Matsubara H, Carey RM, Kramer CM.

Schietinger BJ, Voros S, Isbell DC, Meyer CH, Christopher JM, Kramer CM. Can late gadolinium enhancement by cardiovascular magnetic resonance identify coronary artery disease as the etiology of new onset congestive heart failure? Int J Cardiovasc Imaging. 2007 Oct;23(5):595-602.

Kamran Akram, Szilard Voros. Absolute Coronary Artery Calcium Scores are superior to MESA percentile rank in predicting obstructive coronary artery disease. Int J Cardiovasc Imaging. 2008 Oct;24(7):743-9.

Szilard Voros. Can Computed Tomography Angiography of the Coronary Arteries Characterize Atherosclerotic Plaque Composition? Is the CAT (Scan) Out of the Bag? J. Am. Coll. Cardiol. Intv. 2008;1;183-185.

Kamran Akram, Robert E. O’Donnell, Spencer King, H. Robert Superko, Arthur Agatston, Szilard Voros. Influence of Symptomatic Status on the Prevalence of Obstructive Coronary Artery Disease in Patients with Zero Calcium Score. Atherosclerosis 2009;203:533–537.

Akram K, Voros S. Influence of symptoms and age on the predictive value of coronary artery calcium scanning. J Am Coll Cardiol. 2008 Dec 16;52(25):2214.

Akram K, Rinehart S, Voros S. Coronary arterial atherosclerotic plaque imaging by contrast-enhanced computed tomography: fantasy or reality? J Nucl Cardiol. 2008 Nov-Dec;15(6):818-29.

Voros S. What are the potential advantages and disadvantages of volumetric CT scanning? J Cardiovasc Comput Tomogr. 2009 Mar-Apr;3(2):67-70. Epub 2009 Jan 9.

Rinehart S, Vazquez G, Qian Z, Voros S. Coronary Plaque Imaging with Multi-Slice Computed Tomographic Angiography and Intravascular Ultrasound: A Close Look Inside and Out. J Inv Cardiol 2009; 21(7):367-372.

Qian Z, Marvasty I, Anderson H, Rinehart S, Voros S. "Lesion-specific coronary artery calcium quantification better predicts cardiac events". Proc. of IEEE International Symposium on Biomedical Imaging (ISBI), p237-240, 2009.

Akram K, Anderson HD, Voros S. Quantification of left ventricular parameters obtained by automated software for 64-slice multidetector computed tomography and comparison with magnetic resonance imaging. Cardiovasc Intervent Radiol. 2009 Nov;32(6):1154-60.

Voros S. "Does imaging paint a sugar-coated picture of diabetic vessels?" : plaque composition in diabetics by IVUS and CT angiography. J Nucl Cardiol. 2009 May-Jun;16(3):339-44. Epub 2009 Mar 10. No abstract available.

Voros S, Joshi PH, Vazquez G, Roth G, Murrieta L, Rinehart S, Qian Z, Miller J. Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: Rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study. J Cardiovasc Comput Tomogr. 2010;4:164–172.

George Barbier, Jesus Gustavo Vazquez Figueroa, Sarah Rinehart, Zhen Qian, Parag Joshi, Charles Wilmer, Szilard Voros. Tissue Characterization of a Papillary Fibroelastoma on the Aortic Valve by Contrast-Enhanced 320-Detector Row Computed Tomography Accepted Manuscript, 7 June 2010. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.05.020

Zhen Qian, Hunt Anderson, Idean Marvasty, Kamran Akram, Gustavo Vazquez, Sarah Rinehart, Szilard Voros. Lesion- and Vessel-Specific Coronary Artery Calcium Scores are Superior to Whole-Heart Agatston and Volume Scores in the Diagnosis of Obstructive Coronary Artery Disease. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.09.001.

Sara Mobasseri, Szilard Voros. Clinical Trial Report: The Use of Coronary CT Angiography to Evaluate Chest Pain Patients—The ROMICAT (Rule Out Myocardial Infarction using Computer-Assisted Tomography) Study. Current Cardiovascular Imaging Reports. DOI: 10.1007/s12410-010-9051-7.

Rinehart S, Vazquez G, Qian Z, Murrieta L, Christian K, Voros S. Quantitative Measurements of Coronary Arterial Stenosis, Plaque Geometry and Composition are Highly Reproducible with a Standardized Coronary Arterial Computed Tomographic Approach in High-Quality CT Datasets. J Cardiovasc Comput Tomogr. 2011 Jan-Feb;5(1):35-43. Epub 2010 Oct 1.

Liu Q, Qian Z, Marvasty I, Rinehart S, Voros S, Metaxas DN. Lesion-specific coronary artery calcium quantification for predicting cardiac event with multiple instance support vector machines. Med Image Comput Comput Assist Interv. 2010;13(Pt 1):484-92.

Joshi PH, Krivitsky E, Qian Z, Vazquez G, Voros S, Miller J. Do We Know When and How to Lower Lipoprotein(a)? Curr Treat Options Cardiovasc Med. 2010 Aug;12(4):396-407.

Steven Rosenberg, PhD; Michael R. Elashoff, PhD; Philip Beineke, BS; Susan E. Daniels, PhD; James A. Wingrove, PhD; Whittemore G. Tingley, MD, PhD; Philip T. Sager, MD; Amy J. Sehnert, MD; May Yau, MS; William E. Kraus, MD; L. Kristin Newby, MD; Robert S. Schwartz, MD; Szilard Voros, MD; Stephen G. Ellis, MD; Naeem Tahirkheli, MD; Ron Waksman, MD; John McPherson, MD; Alexandra Lansky, MD; Mary E. Winn, BS; Nicholas J. Schork, PhD; and Eric J. Topol, MD, for the PREDICT (Personalized Risk Evaluation and Diagnosis in the Coronary Tree) Investigators. Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients. Ann Intern Med. 2010;153:425-434.

PRACTICE GUIDELINES. 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults. J Am Coll Cardiol, doi:10.1016/j.jacc.2010.09.001. Reviewer on behalf of the Society for Cardiovascular Magnetic Resonance Imaging.

Szilard Voros, Sarah Rinehart, Zhen Qian, Gustavo Vazquez, Hunt Anderson, Laura Murrieta, Charles Wilmer, Harold Carlson, Kenneth Taylor, William Ballard, Dimitri Karmpaliotis, Anna Kalynych, Charles Brown III. Prospective Validation of Standardized, 3-Dimensional, Quantitative Coronary Computed Tomographic Plaque Measurements using Radiofrequency Backscatter Intravascular Ultrasound as Reference Standard in Intermediate Coronary Arterial Lesions: Results from the ATLANTA I Study. JACC Cardiovasc Interv. 2011 Feb;4(2):198-208.

Szilard Voros, MD, Juan J. Rivera, MD, Daniel S. Berman, MD, Ron Blankstein, MD, Matthew J. Budoff, MD, Ricardo C. Cury, MD, Milind Y. Desai, MD, Damini Dey, PhD, Sandra S. Halliburton, PhD, Harvey S. Hecht, MD, Khurram Nasir, MD, MPH, Raul D. Santos, MD, Michael D. Shapiro, DO, Allen J. Taylor, MD, FACC, FAHA, Uma S. Valeti, MD, Phillip M. Young, MD, Gaby Weissman, MD. Guideline for minimizing radiation exposure during acquisition of coronary artery calcium scans with the use of multidetector computed tomography: A report by the Society for Atherosclerosis Imaging-Prevention Tomographic Imaging and Prevention Councils in collaboration with the Society of Cardiovascular Computed Tomography. Journal of Cardiovascular Computed Tomography. In Press. DOI 10.1016/j.jcct.2011.01.003.

Sharma A, Kasim M, Joshi PH, Qian Z, Krivitsky E, Akram K, Rinehart S, Vazquez G, Miller J, Rohman MS, Voros S. Abnormal Lipoprotein(a) Levels Predict Coronary Artery Calcification in Southeast Asians but not in Caucasians: use of noninvasive imaging for evaluation of an emerging risk factor. Journal of Cardiovascular Translational Research. DOI: 10.1007/s12265-011-9273-3. J Cardiovasc Transl Res. 2011 Apr 12.

Michael R Elashoff, James A Wingrove, Philip Beineke, Susan E Daniels, Whittemore G Tingley, Steven Rosenberg, Szilard Voros, William E Kraus, Geoffrey S Ginsburg, Robert S Schwartz, Stephen G Ellis, Naheem Tahirkheli, Ron Waksman, John McPherson, Alexandra J Lansky and Eric J Topol. Development of a Blood-based Gene Expression Algorithm for Assessment of Obstructive Coronary Artery Disease in Non-Diabetic Patients. BMC Medical Genomics 2011, 4:26. doi:10.1186/1755-8794-4-26.

Voros S, Rinehart S, Qian Z, Joshi P, Vazquez G, Fischer C, Belur P, Hulten E, Villines TC. Coronary Atherosclerosis Imaging by Coronary CT Angiography Current Status, Correlation With Intravascular Interrogation and Meta-Analysis. JACC Cardiovasc Imaging. 2011 May;4(5):537-48.

Qian Z, Joshi PH, Shaukat AF, Laury T, Kirkland B, Meyers L, Drew A, Angel E, Krivitsky E, Bajpai A, Vazquez G, O'Rourke C, Carr JJ, Rinehart S, Voros S. Relationship between chest lateral width, tube current, image noise, and radiation exposure associated with coronary artery calcium scanning on 320-detector row CT. J Cardiovasc Comput Tomogr. 2011 July - August;5(4):231-239. Epub 2011 Jun 12.

R. Hachamovitch, B. Nutter, M.A. Hlatky, L.J. Shaw, M.L. Ridner, S. Dorbala, R.S.B. Beanlands, B.J.W. Chow, E. Branscomb, P. Chareonthaitawee, W.G. Weigold, S.Voros, S. Abbara, T. Yasuda, J.E. Jacobs, J. Lesser, D.S. Berman, L. Thomson, S. Raman, G.V. Heller, A. Schussheim, R. Brunken, K.A. Williams, S. Farkas, D. Delbeke, U. J. Schoepf, N. Reichek, S. Rabinowitz, S.R. Sigman, R. Patterson, C.R. Corn, R. White, Ella Kazerooni, J. Corbett, S. Bokhari, J. Machac, M. Guarneri, S. Borges-Neto, J.W. Millstine, J. Caldwell, Arrighi, U. Hoffmann, M. Budoff, J.Lima,35 J.R. Johnson,2 B. Johnson,2 M. Gaber,2 J. A. Williams,2 C. Foster, J. Hainer, M.F.Di Carli, for the SPARC study Investigators. Patient Management after Non-invasive Cardiac Imaging: Results From the Study of Myocardial Perfusion and Coronary Anatomy Imaging Roles in Coronary Artery Disease (SPARC). J Am Coll Cardiol. In Press.

Rinehart S, Qian Z, Vazquez G, Joshi P, Kirkland B, Bhatt K, Marvasty I, Christian K, Voros S. Demonstration of the Glagov phenomenon in vivo by CT coronary angiography in subjects with elevated Framingham risk. Int J Cardiovasc Imaging; DOI 10.1007/s10554-011-9979-y.

Using high resolution cardiac CT data to model and visualize patient-specific interactions between trabeculae and blood flow. Kulp S, Gao M, Zhang S, Qian Z, Voros S, Metaxas D, Axel L. Med Image Comput Comput Assist Interv. 2011;14(Pt 1):468-75.

A lesion-specific coronary artery calcium quantification framework for the prediction of cardiac events. IEEE Trans Inf Technol Biomed. 2011 Sep;15(5):673-80. Epub 2011 Jul 14. Qian Z, Marvasty I, Rinehart S, Voros S.

Voros S, Qian Z. Agatston score tried and true: By contrast, can we quantify calcium on CTA? Journal of Cardiovascular Computed Tomography (2012) 6, 45–47.

References