Synaptotagmins

Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B.

There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins.

Members

Synaptotagmin 1 (SYT1)
Synaptotagmin 2 (SYT2)
Synaptotagmin 3 (SYT3)
Synaptotagmin 4 (SYT4)
Synaptotagmin 5 (SYT5)
Synaptotagmin 6 (SYT6)
Synaptotagmin 7 (SYT7)
Synaptotagmin 8 (SYT8)
Synaptotagmin 9 (SYT9)
Synaptotagmin 10 (SYT10)

External links

UMich Orientation of Proteins in Membranes families/superfamily-47 - Orientations of C2 domains in the lipid bilayer
Synaptotagmins at the US National Library of Medicine Medical Subject Headings (MeSH)

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Ion pumps	SERCA Sodium-calcium exchanger

Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor

Adhesion molecules	Cadherin

Other	Calcium-sensing receptor

Intracellular signaling
& calc. regulation

Second messengers	IP3 NAADP cADPR

Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor

Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS

Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins

Proteases	Calpain

Cytoskeleton remodeling proteins	Gelsolin

Chaperones	Calreticulin Calnexin

Other	Vitamin D

Calcium-binding
protein domains

Extracellular ligands

Calcium-binding proteins

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin

Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin

Cytoskeleton	Troponin C

Extracellular matrix	Matrix gla protein

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Ion pumps	SERCA Sodium-calcium exchanger

Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor

Adhesion molecules	Cadherin

Other	Calcium-sensing receptor

Intracellular signaling
& calc. regulation

Second messengers	IP3 NAADP cADPR

Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor

Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS

Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins

Proteases	Calpain

Cytoskeleton remodeling proteins	Gelsolin

Chaperones	Calreticulin Calnexin

Other	Vitamin D

Calcium-binding
protein domains

Extracellular ligands

Calcium-binding proteins

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin

Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin

Cytoskeleton	Troponin C

Extracellular matrix	Matrix gla protein

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6

R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Synaptotagmin

SYT1
SYT2
SYT3
SYT4
SYT5
SYT6
SYT7
SYT8
SYT9
SYT10
SYT11
SYT12
SYT13
SYT14
SYT15
SYT16
SYT17

Other

Small GTPase: RAB3A

COPI

Coatomer
- COPA
- COPB1
- COPB2
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Archain

Small GTPase: ARF

COPII

Vesicle formation: SEC23A

Small GTPase: SAR1A

RME/Clathrin

CLTA
CLTB
CLTC

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3

Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1

Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2

Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1

LMAN1

LYST

BLOC-1:	DTNBP1 BLOC153

BLOC-2:	HPS3 HPS5 HPS6

BLOC-3:	HPS1 HPS4

Coats:	Retromer TIP47

Small GTPase

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins