Sulfalene

Systematic (IUPAC) name
4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
Clinical data
Trade names	Eadazine, Kelfizina, Kelfizine W, Longum
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral[1]
Pharmacokinetic data
Protein binding	60 to 80%[1]
Half-life	60 to 65 hours[1]
Excretion	Urinary[1]
Identifiers
CAS Registry Number	152-47-6 Y
ATC code	J01ED02 QJ01EQ19
PubChem	CID 9047
DrugBank	DB00664 Y
ChemSpider	8695 Y
UNII	T6BL4ZC15G Y
KEGG	D01216 Y
Synonyms	Sulfametopyrazine
Chemical data
Formula	C11H12N4O3S
Molecular mass	280.304 g/mol
SMILES O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2
InChI InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)  Y Key:KXRZBTAEDBELFD-UHFFFAOYSA-N  Y
Y (what is this?)  (verify)

Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.^[2][3] There are only two countries in which it is currently still marketed: Thailand and Ireland.^[3]

Synthesis

Sulfalene synthesis: GB 928151  U.S. Patent 3,098,069 ^[4]

See also

• Sulfadoxine

References

1. ↑ 1.0 1.1 1.2 1.3 "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011. 
2. ↑ DrugBank DB00664
3. ↑ 3.0 3.1 Brayfield, A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014. 
4. ↑ Camerino, B.; Palamidessi, G., Gazz. Chim. Ital., (1960) 90, 1815.