Stephen O'Rahilly

Sir Stephen O'Rahilly
Born Stephen Patrick O'Rahilly
1 April 1958[1]
Citizenship Ireland, United Kingdom
Fields
Institutions
Alma mater University College Dublin
Notable awards

Website

Sir Stephen Patrick O'Rahilly MD FRS FRCP FRCP FRCPath FRS FMedSci is an Irish-British physician and Professor known for his research into the molecular pathogenesis of human obesity, insulin resistance and related metabolic and endocrine disorders.[2][3][4][5][6][7][8][9][10]

Education

O'Rahilly was raised in Dublin, Ireland[11] and educated at Beneavin College.[1] He attended University College Dublin to study medicine[11]

Research

O'Rahilly has undertaken research at the University of Oxford and Harvard Medical School into diabetes and insulin resistance, before joining the University of Cambridge where he is a Professor of Clinical Biochemistry and Medicine, Director of the University of Cambridge Metabolic Research Laboratories,[12] Director of the MRC Metabolic Diseases Unit,[12] co-director of the Wellcome Trust-MRC Institute of Metabolic Science, Scientific Director of the NIHR Cambridge Biomedical Research Centre, Associate Faculty at the Wellcome Trust Sanger Institute and honorary consultant physician at Addenbrooke's Hospital, Cambridge.[13][14][15]

Awards and honours

O'Rahilly was elected to the Academy of Medical Sciences in 1999, the Royal Society in 2003. His nomination reads:

“ Stephen O'Rahilly has made major contributions to the understanding of the molecular mechanisms underlying human disorders of energy balance and metabolism. His work first established that mutations in single genes could result in severe human obesity and that these defects largely acted through disruption of central satiety mechanisms. These findings have altered clinical approaches to the evaluation of the obese child and have identified a subtype of obesity amenable to dramatically effective therapy. His studies of patients with extreme insensitivity to insulin have also provided new insights into human insulin action and its disruption in states of insulin resistance.[16] ”

Rahilly became a Foreign Associate of the National Academy of Sciences, in the US in 2011. He was awarded the Heinrich Wieland Prize[17] in 2002, the InBev-Baillet Latour Health Prize in 2010[18] and the Debrecen Award for Molecular Medicine in 2014.[19]

He was knighted in the 2013 Birthday Honours for services to medical research.[20][21]

References

  1. ↑ 1.0 1.1 1.2 1.3 O’RAHILLY, Prof. Stephen. Who's Who 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. ↑ Neill, U. S. (2013). "A conversation with Stephen O'Rahilly". Journal of Clinical Investigation 123 (6): 2335–2336. doi:10.1172/JCI70726. PMC 3668822. PMID 23722908.
  3. ↑ Weston, K. (2011). "Translating metabolic biochemistry into the clinic: An interview with Steve O'Rahilly". Disease Models & Mechanisms 4 (2): 141–144. doi:10.1242/dmm.007641.
  4. ↑ Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.
  5. ↑ Stephen O'Rahilly's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  6. ↑ Oʼrahilly, Stephen; Montague, C. T.; Farooqi, I. S.; Whitehead, J. P.; Soos, M. A.; Rau, H.; Wareham, N. J.; Sewter, C. P.; Digby, J. E.; Mohammed, S. N.; Hurst, J. A.; Cheetham, C. H.; Earley, A. R.; Barnett, A. H.; Prins, J. B. (1997). "Congenital leptin deficiency is associated with severe early-onset obesity in humans". Nature 387 (6636): 903–8. doi:10.1038/43185. PMID 9202122.
  7. ↑ Seminara, S. B.; Messager, S.; Chatzidaki, E. E.; Thresher, R. R.; Acierno, J. S.; Shagoury, J. K.; Bo-Abbas, Y.; Kuohung, W.; Schwinof, K. M.; Hendrick, A. G.; Zahn, D.; Dixon, J.; Kaiser, U. B.; Slaugenhaupt, S. A.; Gusella, J. F.; O'Rahilly, S.; Carlton, M. B. L.; Crowley, W. F.; Aparicio, S. A. J. R.; Colledge, W. H. (2003). "TheGPR54Gene as a Regulator of Puberty". New England Journal of Medicine 349 (17): 1614–27. doi:10.1056/NEJMoa035322. PMID 14573733.
  8. ↑ Farooqi, I. S.; Jebb, S. A.; Langmack, G.; Lawrence, E.; Cheetham, C. H.; Prentice, A. M.; Hughes, I. A.; McCamish, M. A.; O'Rahilly, S. (1999). "Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency". New England Journal of Medicine 341 (12): 879. doi:10.1056/NEJM199909163411204.
  9. ↑ Payne, F.; Lim, K.; Girousse, A.; Brown, R. J.; Kory, N.; Robbins, A.; Xue, Y.; Sleigh, A.; Cochran, E.; Adams, C.; Dev Borman, A.; Russel-Jones, D.; Gorden, P.; Semple, R. K.; Saudek, V.; O'Rahilly, S.; Walther, T. C.; Barroso, I.; Savage, D. B. (2014). "Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease". Proceedings of the National Academy of Sciences 111 (24): 8901. doi:10.1073/pnas.1408523111.
  10. ↑ "Professor Steve O'Rahilly, Head of Department and Professor of Clinical Biochemistry and Medicine". University of Cambridge. Archived from the original on 2014-04-13.
  11. ↑ 11.0 11.1 Ellen Ruppel Shell, Fat Genes, Discover Magazine, May 1, 2000
  12. ↑ 12.0 12.1 "Stephen O'Rahilly, University of Cambridge Metabolic Research Laboratories". Archived from the original on 2014-06-14.
  13. ↑ "NIHR Cambridge Biomedical Research Centre Web Site". Archived from the original on 2014-05-03.
  14. ↑ Roberts, E. W.; Deonarine, A; Jones, J. O.; Denton, A. E.; Feig, C; Lyons, S. K.; Espeli, M; Kraman, M; McKenna, B; Wells, R. J.; Zhao, Q; Caballero, O. L.; Larder, R; Coll, A. P.; O'Rahilly, S; Brindle, K. M.; Teichmann, S. A.; Tuveson, D. A.; Fearon, D. T. (2013). "Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia". Journal of Experimental Medicine 210 (6): 1137–51. doi:10.1084/jem.20122344. PMC 3674708. PMID 23712428.
  15. ↑ Loos, R. J.; Lindgren, C. M.; Li, S; Wheeler, E; Zhao, J. H.; Prokopenko, I; Inouye, M; Freathy, R. M.; Attwood, A. P.; Beckmann, J. S.; Berndt, S. I.; Prostate, Lung; Jacobs, K. B.; Chanock, S. J.; Hayes, R. B.; Bergmann, S; Bennett, A. J.; Bingham, S. A.; Bochud, M; Brown, M; Cauchi, S; Connell, J. M.; Cooper, C; Smith, G. D.; Day, I; Dina, C; De, S; Dermitzakis, E. T.; Doney, A. S. et al. (2008). "Common variants near MC4R are associated with fat mass, weight and risk of obesity". Nature Genetics 40 (6): 768–75. doi:10.1038/ng.140. PMC 2669167. PMID 18454148.
  16. ↑ "EC/2003/27: O'Rahilly, Stephen Patrick". London: The Royal Society. Archived from the original on 2014-11-10.
  17. ↑ Heinrich Wieland Prize
  18. ↑ "Professor Stephen O'Rahilly wins the 2010 InBev-Baillet Latour Prize". Disease Models & Mechanisms 3 (7–8): 402. 2010. doi:10.1242/dmm.006080. PMID 20610691.
  19. ↑ "Debrecen Award for Molecular Medicine". University of Debrecen. Retrieved 7 January 2015.
  20. ↑ The London Gazette: (Supplement) no. 60534. p. 1. 2013-06-15.
  21. ↑ Stephen O'Rahilly knighted, BBC News, 14 June, 3013