Spondin 1

Spondin 1, extracellular matrix protein

PDB rendering based on 1szl.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2ZOT, 2ZOU, 3COO, 3Q13

Identifiers

Symbols

SPON1 ; VSGP/F-spondin; f-spondin

External IDs

OMIM: 604989 MGI: 2385287 HomoloGene: 4453 GeneCards: SPON1 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• proteinaceous extracellular matrix • extracellular space • extracellular matrix
Biological process	• cell adhesion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
13.98 – 14.29 Mb

Chr 7:
113.77 – 114.04 Mb

PubMed search

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.^[1] It is secreted by cells of the floor plate and may be involved in axon guidance^[2] The protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

References

↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
↑ "Entrez Gene: SPON1 spondin 1, extracellular matrix protein".

Nakajima D, Okazaki N, Yamakawa H, (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Klar A, Baldassare M, Jessell TM (1992). "F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension". Cell 69 (1): 95–110. doi:10.1016/0092-8674(92)90121-R. PMID 1555244.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Miyamoto K, Morishita Y, Yamazaki M, (2001). "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary". Arch. Biochem. Biophys. 390 (1): 93–100. doi:10.1006/abbi.2001.2367. PMID 11368520.
Gonzalez de Peredo A, Klein D, Macek B, (2002). "C-mannosylation and o-fucosylation of thrombospondin type 1 repeats". Mol. Cell Proteomics 1 (1): 11–8. doi:10.1074/mcp.M100011-MCP200. PMID 12096136.
Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ho A, Südhof TC (2004). "Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2548–53. doi:10.1073/pnas.0308655100. PMC 356987. PMID 14983046.
Gerhard DS, Wagner L, Feingold EA, (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pyle-Chenault RA, Stolk JA, Molesh DA, (2005). "VSGP/F-spondin: a new ovarian cancer marker". Tumour Biol. 26 (5): 245–57. doi:10.1159/000087379. PMID 16103746.
Otsuki T, Ota T, Nishikawa T, (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kitagawa M, Kudo Y, Iizuka S, (2006). "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells". Biochem. Biophys. Res. Commun. 349 (3): 1050–6. doi:10.1016/j.bbrc.2006.08.142. PMID 16965763.

PDB gallery

1szl: F-spondin TSR domain 1

1vex: F-spondin TSR domain 4

Spondin 1

References

Further reading