Speke (disambiguation)
Speke may refer to:
- Speke, Liverpool district
- Mount Speke, a mountain in the Ruwenzori Range, Africa.
- John Hanning Speke (1827–1864), explorer of Central Africa
- PS Speke, a Uganda Railway paddle steamer named after John Hanning Speke
- SPEKE (Simple Password Exponential Key Exchange), cryptographic protocol