Sophia Frangou

Sophia Frangou (Greek: Σοφία Φράγκου) is Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai where she heads the Psychosis Research Program. She is a Fellow of the Royal College of Psychiatrists^[1] and of the European Psychiatric Association (EPA) and Vice-President for Research of the International Society for Bipolar Disorders. She is secretary and founding member of the EPA NeuroImaging section and heads the Brain Imaging Network of the European College of Neuropsychopharmacology. She is one of the three Editors of European Psychiatry,^[2] the official Journal of the European Psychiatric Association. She has also served on the Council of the British Association for Psychopharmacology.

Biography

Frangou graduated from the Medical School of the University of Athens, Greece in 1989. She then moved to the UK where she trained in psychiatry at the Maudsley Hospital, London. She obtained her Masters Degree in Neuroscience from the University of London, UK and trained in the US as a research fellow at the Department of Psychiatry and Behavioural Sciences at the Johns Hopkins University She returned to the Institute of Psychiatry, King's College London where she completed her PhD on neuroimaging and electrophysiological markers of familial vulnerability to schizophrenia. Between 1997 and 2013 she worked as a Consultant Psychiatrist at the Maudsley Hospital and led her own research group at the Institute of Psychiatry, King's College London.

Research

Frangou's research focuses on the pathophysiological processes underlying psychosis, with emphasis on schizophrenia and bipolar disorder using clinical, genetic, cognitive and neuroimaging techniques. Her key contributions in the field relate to the neurobiological correlates that influence the age when psychosis becomes clinical apparent and on the functional impact of susceptibility genes for schizophrenia and bipolar disorder on brain structure and function. More recently her work is focused on the examination of biological processes that determine resilience to mental illness and differentiate bipolar disorder from schizophrenia.

In parallel Frangou is also interested in the standardisation of cognitive test batteries for the assessment of cognition in psychosis as a means to facilitating large scale international collaborative research such as the ISBD neurocognition initiative ISBD-BANC.^[3]

Recent publications

• Rocha-Rego, V.; Jogia, D.; Marquand, AF.; Mourao-Miranda, J.; Simmons, A.; Frangou, S. (2013). "Examination of the predictive value of structural magnetic resonance scans in bipolar disorder: a pattern classification approach.". Psychol Med June (5): 1–14. doi:10.1017/S0033291713001013. PMID 23734914. View article here
• Dima, D.; Stephan, KE.; Roiser, JP.; Friston, KJ.; Frangou, S. (2011). "Effective Connectivity during Processing of Facial Affect: Evidence for Multiple Parallel Pathways.". J Neurosci 31 (40): 14378–14385. doi:10.1523/JNEUROSCI.2400-11.2011. PMID 21976523. View article here
• Roussos, P.; Katsel, P.; Davis, KL.; Bitsios, P.; Giakoumaki, SG.; Jogia, J.; Rozsnyai, K.; Collier, D.; Frangou, S.; Frangou, S.; Siever, LJ.; Haroutunian, V. (2011). "Molecular and Genetic Evidence for Abnormalities in the Nodes of Ranvier in Schizophrenia.". Arch Gen Psychiatry 14 (8 Suppl 4): IV44–50; discussion IV51–5. doi:10.1001/archgenpsychiatry.2011.110. PMID 1893642. View article here
• Sugranyes, G.; Kyriakopoulos, M.; Corrigall, R.; Taylor, E.; Frangou, S. (2011). "Autism spectrum disorders and schizophrenia: meta-analysis of the neural correlates of social cognition.". PLoS ONE 6 (140): e25322. doi:10.1371/journal.pone.0025322. PMC 3187762. PMID 21998649. View article here
• Delvecchio, G.; Fossati, P.; Boyer, P.; Brambilla, P.; Falkai, P.; Gruber, O.; Hietala, J.; Lawrie, SM.; Martinot, JL.; McIntosh, MA.; Meisenzahl, E.; Frangou, S. (2011). "Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: A voxel-based meta-analysis of functional magnetic resonance imaging studies.". Eur Neuropsychopharmacol. 22 (2): 100–13. doi:10.1016/j.euroneuro.2011.07.003. PMID 21820878. View article here
• Jogia, J.; Dima, D.; Kumari, V.; Frangou, S. (2011). "Frontopolar cortical inefficiency may underpin reward and working memory dysfunction in bipolar disorder". World J Biol Psychiatry 13 (8): 605. doi:10.3109/15622975.2011.585662. PMID 21812622. View article here
• Kempton, MJ.; Salvador, Z.; Munafò, MR.; Geddes, JR.; Simmons, A.; Frangou, S.; Williams, SC. (2011). "Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder.". Arch Gen Psychiatry 68 (7): 675–90. doi:10.1001/archgenpsychiatry.2011.60. PMID 21727252. View article here
• Pompei, F.; Dima, D.; Rubia, K.; Kumari, V.; Frangou, S. (2011). "Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder.". Neuroimage 57 (2): 576–82. doi:10.1016/j.neuroimage.2011.04.055. PMID 21570470. View article here
• Pompei, F.; Jogia, J.; Tatarelli, R.; Girardi, P.; Rubia, K.; Kumari, V.; Frangou, S. (2011). "Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar Disorder.". Neuroimage 56 (3): 1677–84. doi:10.1016/j.neuroimage.2011.02.052. PMID 21352930. View article here
• Jogian, J.; Ruberto, G.; Lelli-Chiesa, G.; Vassos, E.; Maierú, M.; Tatarelli, R.; Girardi, P.; Collier, D.; Frangou, S. (2011). "The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder". Mol Psychiatry 16 (11): 1070–1. doi:10.1038/mp.2011.49. PMID 21519340. View article here
• Ruberto, G.; Vassos, E.; Lewis, C. M.; Tatarelli, R.; Girardi, P.; Collier, D.; Frangou, S. (2011). Yoshikawa, Takeo, ed. "The Cognitive Impact of the ANK3 Risk Variant for Bipolar Disorder: Initial Evidence of Selectivity to Signal Detection during Sustained Attention". PLoS ONE 6 (1): e16671. doi:10.1371/journal.pone.0016671. PMC 3031622. PMID 21304963. Free text available here
• Perrier, E.; Pompei, F.; Ruberto, G.; Vassos, E.; Collier, D.; Frangou, S. (2011). "Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder". Eur Psychiatry 26 (3): 135–137. doi:10.1016/j.eurpsy.2010.10.004. PMID 21292451. View article here
• Forcada, I.; Papachristou, E.; Mur, M.; Jogia, J.; Reichenberg, A.; Vieta, E.; Frangou, S.; Frangou, Sophia (2010). "The impact of general intellectual ability and white matter volume on the functional outcome of patients with Bipolar Disorder and their relatives". J Affect Disord 130 (3): 413–420. doi:10.1016/j.jad.2010.10.048. PMID 21112093. View article here
• Lelli-Chiesa, G.; Kempton, M. J.; Jogia, J.; Tatarelli, R.; Girardi, P.; Powell, J.; Collier, D. A.; Frangou, S. (2010). "The impact of the Val158Met catechol- O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives". Psychol Med 41 (4): 1–10. doi:10.1017/S0033291710001431. PMID 20667170. 
• Kumar, C.T.S.; Christodoulou, T.; Vyas, N.S.; Kyriakopoulos, M.; Corrigall, R.; Reichenberg, A.; Frangou, S. (2010). "Deficits in visual sustained attention differentiate genetic liability and disease expression for Schizophrenia from Bipolar Disorder". Schiz Res 124 (1–3): 152–160. doi:10.1016/j.schres.2010.07.006. PMID 20674278. 
• Kempton, M. J.; Haldane, M.; Jogia, J.; Grasby, P. M.; Collier, D.; Frangou, S. (2009). "Dissociable Brain Structural Changes Associated with Predisposition, Resilience, and Disease Expression in Bipolar Disorder". J Neurosci 29 (35): 10863–8. doi:10.1523/JNEUROSCI.2204-09.2009. PMID 19726644. 
• Kempton, M. J; Ruberto, G.; Vassos, E.; Tatarelli, R.; Girardi, P.; Collier, D.; Frangou, S. (2009). "Effects of the CACNA1C Risk Allele for Bipolar Disorder on Cerebral Gray Matter Volume in Healthy Individuals". Am J Psychiatry 166 (12): 1413–4. doi:10.1176/appi.ajp.2009.09050680. PMID 19952088. 
• Kyriakopoulos, M.; Perez-Iglesias, R.; Woolley, J. B.; Kanaan, R. A. A.; Vyas, N. S.; Barker, G. J.; Frangou, S.; McGuire, P. K. (2009). "Effect of age at onset of schizophrenia on white matter abnormalities". Br Journal Psychiatry 195 (4): 346–53. doi:10.1192/bjp.bp.108.055376. PMID 19794204. 
• Stefanopoulou, Evgenia; Manoharan, Andiappan; Landau, Sabine; Geddes, John R.; Goodwin, Guy; Frangou, Sophia (2009). "Cognitive functioning in patients with affective disorders and schizophrenia: A meta-analysis". International Review of Psychiatry 21 (4): 336–56. doi:10.1080/09540260902962149. PMID 20374148. 
• Burke, L; Androutsos, C; Jogia, J; Byrne, P; Frangou, S (2008). "The Maudsley Early Onset Schizophrenia Study: The effect of age of onset and illness duration on fronto-parietal gray matter". Eur Psychiatry 23 (4): 233–6. doi:10.1016/j.eurpsy.2008.03.007. PMID 18541416. 

See also

• Institute of Psychiatry
• Maudsley Hospital
• International Society for Bipolar Disorders
• Icahn School of Medicine at Mount Sinai

References