Small nucleolar SNORD12/SNORD106

Small nucleolar SNORD12/SNORD106
Predicted secondary structure and sequence conservation of SNORD12
Identifiers
Symbol SNORD12
Alt. Symbols SNORD106; snoHBII-99
Rfam RF00581
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

In molecular biology, the small nucleolar RNAs SNORD106 and SNORD12 (also known as U106 and HBII-99 respectively ) are two related snoRNAs which belongs to the C/D class of small nucleolar RNAs (snoRNAs). Both contain the conserved C (UGAUGA) and D (CUGA) box sequence motifs [1]

Human SNORD12 (HBII-99) is the homologue of mouse snoRNA MBII-99. In humans both HB11-99 and U106 snoRNAs share the same host gene.[2][3]

Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878.[4] U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA.[5] However, these targets do not appear to be methylated and U106 might function as an RNA chaperone during rRNA folding.[2] A similar role has been suggested for the H/ACA snoRNAs U17a and U17b[2]

References

  1. ↑ Vitali, Patrice; Royo, Hélène; Seitz, Hervé; Bachellerie, Jean‐Pierre; Hüttenhofer, Alexander; Cavaillé, Jérôme (15 November 2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Research 31 (22): 6543–6551. doi:10.1093/nar/gkg849. PMC 275545. PMID 14602913.
  2. ↑ 2.0 2.1 2.2 Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.
  3. ↑ Askarian-Amiri, M. E.; Crawford, J.; French, J. D.; Smart, C. E.; Smith, M. A.; Clark, M. B.; Ru, K.; Mercer, T. R.; Thompson, E. R.; Lakhani, S. R.; Vargas, A. C.; Campbell, I. G.; Brown, M. A.; Dinger, M. E.; Mattick, J. S. (May 2011). "SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer". RNA 17 (5): 878–891. doi:10.1261/rna.2528811. PMC 3078737. PMID 21460236.
  4. ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
  5. ↑ Kiss, Tamás (2002). "Small Nucleolar RNAs". Cell 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.

External links