Small nucleolar RNA snR53

Small nucleolar RNA snR53
Predicted secondary structure and sequence conservation of snoR53
Identifiers
Symbol	snoR53
Alt. Symbols	snR53
Rfam	RF00338
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000593

snoRNA snR53 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR53 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1] snoRNA snR53 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.^[2]

References

External links

• Page for Small nucleolar RNA snR53 at Rfam
• Link to snR53 at the FournierLab/snoRNAdb.