Small nucleolar RNA SNORD95

Small nucleolar RNA SNORD95
Predicted secondary structure and sequence conservation of SNORD95
Identifiers
Symbol SNORD95
Alt. Symbols U95
Rfam RF00189
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA U95 (also known as SNORD95 or Z38) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U95 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U95 was identified by computational screening of the introns of ribosomal protein genes for conserved C/D box sequence motifs and expression experimentally verified by northern blotting.[2] U95 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residues A2802 and C2811.[2][3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ 2.0 2.1 Vitali, Patrice; Royo, Hélène; Seitz, Hervé; Bachellerie, Jean‐Pierre; Hüttenhofer, Alexander; Cavaillé, Jérôme (15 November 2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Research 31 (22): 6543–6551. doi:10.1093/nar/gkg849. PMC 275545. PMID 14602913.
  3. ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.

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