Small nucleolar RNA SNORD94

Small Nucleolar RNA SNORD94
Predicted secondary structure and sequence conservation of SNORD94
Identifiers
Symbol SNORD94
Rfam RF00613
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

Small Nucleolar RNA SNORD94 (also known as U94) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNOR94 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] SNORD94 is predicted to guide the 2'O-ribose methylation of C62 of the snRNA U6.[2]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Vitali P, Royo H, Seitz H, Bachellerie JP, Huttenhofer A, Cavaille J; (2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Res 31: 6543–6551. doi:10.1093/nar/gkg849. PMC 275545. PMID 14602913.

External links