Small nucleolar RNA SNORD87
| Small nucleolar RNA SNORD87 | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of SNORD87 | |
| Identifiers | |
| Symbol | SNORD87 |
| Alt. Symbols | U87 |
| Rfam | RF00439 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
SNORD87 (also known as U87) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryote cell which is a major site of snRNA bio genesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
snoRNA U87 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]
U87 was identified by purification from yeast (Saccharomyces cerevisiae)[3] and is the orthologue of mouse MBII-276[4]
References
- ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- ↑ Kiss, Tamás (2002). "Small Nucleolar RNAs". Cell 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
- ↑ Gogolevskaya, Irina K.; Makarova, Julia A.; Gause, Larisa N.; Kulichkova, Valentina A.; Konstantinova, Irina M.; Kramerov, Dmitri A. (12 June 2002). "U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells". Gene 292 (1–2): 199–204. doi:10.1016/S0378-1119(02)00678-9. PMID 12119114.
- ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
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