Small nucleolar RNA SNORD73

Small nucleolar RNA SNORD73
Predicted secondary structure and sequence conservation of SNORD73
Identifiers
Symbol SNORD73
Alt. Symbols U73
Rfam RF00071
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA U73 (also known as SNORD73) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA).[2] U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA.[3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Rebane, A; Tamme R; Laan M; Pata I; Metspalu A (1998). "A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes". Gene 210 (2): 255–263. doi:10.1016/S0378-1119(98)00070-5. PMID 9573378.
  3. ↑ Rebane, A; Roomere H; Metspalu A. (2002). "Locations of several novel 2'-O-methylated nucleotides in human 28S rRNA". BMC Mol Biol. 3: 1. doi:10.1186/1471-2199-3-1. PMC 88882. PMID 11897011.

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