Small nucleolar RNA SNORD48

Small nucleolar RNA SNORD48
Predicted secondary structure and sequence conservation of SNORD48
Identifiers
Symbol SNORD48
Alt. Symbols U48
Rfam RF00282
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

SNORD48 (also known as U48) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

U48 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting.[2] SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279.[3] In the human genome this snoRNA is located in the introns of the same host gene (C6orf48) as another C/D box snoRNA U52 (also known as SNORD52).[3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Kiss-Laszlo, Z; Henry Y; Bachellerie JP; Caizergues-Ferrer M; Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell 85 (7): 1077–1088. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114.
  3. ↑ 3.0 3.1 Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.

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