Small nucleolar RNA SNORD46

Small nucleolar RNA SNORD46
Predicted secondary structure and sequence conservation of SNORD46
Identifiers
Symbol SNORD46
Alt. Symbols U40
Rfam RF00218
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA U46 (also known as SNORD46) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U46 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U46 is encoded in intron 2 of the ribosomal protein S8 gene in human, and is hypothesised to guide methylation of 2'-O-ribose residues on 28S ribosomal RNA (rRNA).[2][3] The homologue of this snoRNA in Arabidopsis thaliana is called snoZ153.[4] Some human U40 sequences have been annotated in the sequence databases (Genbank) as U46.

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Nicoloso, M; Qu LH; Michot B; Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J Mol Biol 260 (2): 178–195. doi:10.1006/jmbi.1996.0391. PMID 8764399.
  3. ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.
  4. ↑ Chen, CL; Liang D; Zhou H; Zhuo M; Chen YQ; Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res 31 (10): 2601–2613. doi:10.1093/nar/gkg373. PMC 156054. PMID 12736310.

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