Small nucleolar RNA SNORA72

Small nucleolar RNA SNORA72
Predicted secondary structure and sequence conservation of SNORA72
Identifiers
Symbol SNORA72
Alt. Symbols U72
Rfam RF00139
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

Small nucleolar RNA SNORA72 (also known as U72) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

ACA30 was originally cloned from HeLa cells [1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA72 is predicted to guide the pseudouridylation of U55 of 5.8S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

References

  1. Ganot, Philippe; Caizergues-Ferrer, Michèle; Kiss, Tamás (1 April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development 11 (7): 941–956. doi:10.1101/gad.11.7.941. PMID 9106664.

External links