Small nucleolar RNA SNORA57

Small nucleolar RNA SNORA57
Predicted secondary structure and sequence conservation of SNORA57
Identifiers
Symbol SNORA57
Alt. Symbols U99
Rfam RF00191
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

Small nucleolar RNA SNORA57 (also known as U99 and MBI-64) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

ACA57 was originally cloned from a mouse brain library [1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA57 is predicted to guide the pseudouridylation of U1004 of 18S ribosomal RNA (rRNA). Pseudouridylation is the isomerisation of the nucleoside uridine to the different isomeric form pseudouridine.

References

  1. Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.

External links