Small nucleolar RNA SNORA48

Small nucleolar RNA SNORA48
Predicted secondary structure and sequence conservation of SNORA48
Identifiers
Symbol SNORA48
Alt. Symbols snoACA48
Rfam RF00554
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

Small nucleolar RNA SNORA48 is a pseudouridylation guide H/ACA box snoRNA. This snoRNA was cloned in 2004[1] from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U3797 of 28S rRNA.

The pseudouridylation of this residue was previously reported in 1997.[2] The H/ACA box snoRNAs ACA48 and U67, and the C/D box snoRNA mgU6-77, share the same host gene (EIF4A1).

References

  1. Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  2. Ofengand, J; Bakin A (1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". J Mol Biol. 266 (2): 246268. doi:10.1006/jmbi.1996.0737. PMID 9047361.

External links