Small nucleolar RNA SNORA43

Small nucleolar RNA SNORA43
Predicted secondary structure and sequence conservation of SNORA43
Identifiers
Symbol	SNORA43
Alt. Symbols	snoACA43
Rfam	RF00416
Other data
RNA type	Gene; snRNA; snoRNA; HACA-box
Domain(s)	Eukaryota
GO	0006396 0005730
SO	0000594

Small nucleolar RNA SNORA43 (also known as ACA43) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

ACA43 was originally cloned from HeLa cells^[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA43 is predicted to guide the pseudouridylation of U4938 of 28S ribosomal RNA (rRNA). Pseudouridylation is the isomerisation of the nucleoside uridine to the different isomeric form pseudouridine.

References

External links

• Page for Small nucleolar RNA SNORA43 at Rfam
• Entry for ACA43 at snoRNABase