Small nucleolar RNA SNORA40

Small nucleolar RNA SNORA40
Predicted secondary structure and sequence conservation of SNORA40
Identifiers
Symbol SNORA40
Alt. Symbols snoACA40
Rfam RF00561
Other data
RNA type Gene; snRNA; snoRNA; HACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

The small nucleolar RNA ACA40 belongs to the H/ACA family of snoRNAs and guides the pseudouridylation of 28S rRNA subunit at position U4565. snoRNA ACA40 was originally discovered using large-scale cloning by Kiss et al. (2004)[1] from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues 28S rRNA U4546 and 18S rRNA 1174.[1][2] The pseudouridylation of these residues was previously reported by Ofengand and Bakin (1997) [3] and Maden (1990).[4] ACA1, ACA8, ACA18, ACA25, ACA32 and ACA40 and the C/D box snoRNAs mgh28S-2409 and mgh28S-2411 share the same host gene (MGC5306).

References

  1. ↑ 1.0 1.1 Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  2. ↑ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.
  3. ↑ Ofengand, J; Bakin A (1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". J Mol Biol. 266 (2): 246–268. doi:10.1006/jmbi.1996.0737. PMID 9047361.
  4. ↑ Maden BE (1990). "The numerous modified nucleotides in eukaryotic ribosomal RNA". Prog. Nucleic Acid Res. Mol. Biol. 39: 241–303. doi:10.1016/S0079-6603(08)60629-7. PMID 2247610.

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