Small nucleolar RNA SNORA11

Small nucleolar RNA SNORA11
Predicted secondary structure and sequence conservation of SNORA11
Identifiers
Symbol SNORA11
Rfam RF00614
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

Small nucleolar RNA SNORA11 (also known as U107) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

U107 has a predicted hairpin-hinge-hairpin-tail structure and is predicted to be a member of the H/ACA box class of snoRNAs that guide the sites of modification of uridines to pseudouridines.[1] This snoRNA was identified by RT-PCR from blood cells and its expression confirmed by Northern blot analysis.[2] There is no predicted RNA target for this guide snRNA.[3]

References

  1. ↑ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  2. ↑ Gu, Ai-Di; Zhou, Hui; Yu, Chun-Hong; Qu, Liang-Hu (2005). "A novel experimental approach for systematic identification of box H/ACA snoRNAs from eukaryotes". Nucleic Acids Research 33 (22): e194. doi:10.1093/nar/gni185. PMC 1316117. PMID 16361266.
  3. ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.

External links