Shoukhrat Mitalipov

Shoukhrat Mitalipov
Born 1961
Citizenship American[1]
Alma mater Timiryazev Agricultural Academy
Research Centre of Medical Genetics
Occupation Scientist
Known for Stem cell breakthrough

Shoukhrat Mitalipov (Shoe-KHRAHT Mee-tuhl-EE-pov)[2] is an American biologist who heads the Center for Embryonic Cell and Gene Therapy at the Oregon Health & Science University in Portland.[3] He is known for discovering a controversial genetic therapy that may be a way to prevent mitochondrial diseases, as well as a new way of creating human stem cells from skin cells.[3][4]

Early life

Mitalipov was born in 1961 in Almaty, Kazakhstan, then part of the Soviet Union.[3] He is of Uyghur ancestry.[1] He served two years in Soviet military, beginning in 1979, as an army radio technician.[1]

Education

After the military, Mitalipov studied genetics at the Timiryazev Agricultural Academy in Moscow, and also played blues guitar in a cover band to pay the bills.[3] He received his master's degree in 1989.[3] He earned his Ph.D. in developmental and stem cell biology from the Research Centre of Medical Genetics in Moscow.[3] Since the fall of the Soviet Union in 1991, funding for stem cell research was scarce, so Mitalipov applied for and won a fellowship at Utah State University in 1995.[3] He started working at the Oregon National Primate Research Center in 1998, where he could work with monkeys, which share 98% of their DNA with humans; at Utah State Mitalipov had worked with cow DNA.[3]

Breakthroughs

A therapy for mitochondrial diseases that Mitalipov discovered, the "spindle transfer" technique, involves removing the nucleus from a human egg and placing it into another.[2][3] If the egg is fertilized, in genetic terms it would have three parents.[3] Mitalipov has successfully bred "three-parent" rhesus macaques.[3] The possibility of using the procedure on human eggs has raised safety and ethics questions.[3]

In May 2013, Mitalipov and his team published a study in Cell that describes a new process for creating human stem cells from skin cells.[4] The stem cell discovery made several journals' "Top 10" scientific breakthrough lists in 2013, including Nature, Science, Time, Discover, National Geographic, and The Week.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 Budnick, Nick (June 2, 2013). "Oregon Stem-cell Groundbreaker Stirs International Frenzy with Cloning Advance". The Oregonian. Retrieved March 4, 2015.
  2. ↑ 2.0 2.1 Tavernise, Sabrina (March 17, 2014). "His Fertility Advance Draws Ire". The New York Times. Retrieved March 4, 2015.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 3.10 3.11 Moore, Elizabeth Armstrong (September 17, 2014). "Splice of Life". Willamette Week. p. 12. Retrieved March 4, 2015.
  4. ↑ 4.0 4.1 4.2 "About Us". Center for Embryonic Cell and Gene Therapy. Retrieved March 4, 2015.

External links