Selenophosphate synthetase 1
| Selenophosphate synthetase 1 | |||||||||||||
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 Rendering based on PDB 3FD5. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SEPHS1 ; SELD; SPS; SPS1 | ||||||||||||
| External IDs | OMIM: 600902 MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1 Gene | ||||||||||||
| EC number | 2.7.9.3 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 22929 | 109079 | |||||||||||
| Ensembl | ENSG00000086475 | ENSMUSG00000026662 | |||||||||||
| UniProt | P49903 | Q8BH69 | |||||||||||
| RefSeq (mRNA) | NM_001195602 | NM_175400 | |||||||||||
| RefSeq (protein) | NP_001182531 | NP_780609 | |||||||||||
| Location (UCSC) | Chr 10: 13.36 – 13.39 Mb | Chr 2: 4.88 – 4.91 Mb | |||||||||||
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Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.[1][2]
This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.[2]
References
- ↑ Low SC, Harney JW, Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.
- ↑ 2.0 2.1 "Entrez Gene: SEPHS1 selenophosphate synthetase 1".
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Tamura T, Yamamoto S, Takahata M et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. doi:10.1073/pnas.0406313101. PMC 528966. PMID 15534230.
- Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Saiki R, Nagata A, Kainou T et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.". FEBS J. 272 (21): 5606–22. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699.
- Chung HJ, Yoon SI, Shin SH et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression.". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID 16786570.