Scissile bond

In molecular biology, a scissile bond is a covalent chemical bond that can be broken by an enzyme. Examples would be the cleaved bond in the self-cleaving hammerhead ribozyme[1] or the peptide bond of a substrate cleaved by a peptidase.[2]

References

  1. ↑ Murray JB, Scott WG (February 2000). "Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?". J. Mol. Biol. 296 (1): 33–41. doi:10.1006/jmbi.1999.3428. PMID 10656816.
  2. ↑ Bauer CA, Thompson RC, Blout ER (March 1976). "The active centers of Streptomyces griseus protease 3, alpha-chymotrypsin, and elastase: enzyme-substrate interactions close to the scissile bond". Biochemistry 15 (6): 1296–9. doi:10.1021/bi00651a020. PMID 814925.