Sarah Teichmann

Sarah Teichmann
Born Sarah Amalia Teichmann
April 15, 1975[1]
Nationality
  • German
  • American[1]
Fields
Institutions
Alma mater
Thesis Genome evolution: analysing proteomes with new methods (1999)
Doctoral advisor Cyrus Chothia[3][4]
Other academic advisors Janet Thornton[5][6][7]
Doctoral students
Other notable students
Notable awards
Children 2 daughters[6]
Website
www.teichlab.org

Sarah Amalia Teichmann (born 1975)[1] is a research group leader at the European Bioinformatics Institute and the Wellcome Trust Sanger Institute.[3][26][27][28] She is also a Principle Research Associate (equivalent to Reader)[29] at the Cavendish Laboratory, and a fellow of Trinity College, Cambridge.

Education

Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993.[9] Teichmann went on to study Natural Sciences (Biochemistry) at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia[30] at the Laboratory of Molecular Biology (LMB) on genome evolution.[31]

Career

Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College London and funded by the Beit Memorial Fellowships for Medical Research. From 2001-2012, she was a Medical Research Council (MRC) Programme Leader, studying patterns in protein interactions and transcriptional regulatory networks.[11][32]

In 2013 Teichmann was appointed a joint position at the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI). Since 2005 she has been a teaching fellow and Director of Studies at Trinity College, Cambridge, and a Principal Research Associate[29] at the Cavendish (Physics) Laboratory at the University of Cambridge since 2013.

Research

Teichmann's research[33][34][35][36][37] investigates gene expression[38][39][40] and protein complex assembly[41] using both wet laboratory and computational biology techniques.[42] In particular her research group:

“ ...seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.[43] ”

Teichmann's research has been funded by the European Research Council (ERC), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC),[44] the Wellcome Trust, the European Molecular Biology Organization (EMBO), the Framework Programmes for Research and Technological Development and the European Cooperation in Science and Technology (COST).[9]

As of 2015 Teichmann has supervised eight PhD students to completion[8][9][10][12][13][14][15][16][17][18] and several postdoctoral researchers who have gone on to become Principal Investigators (PIs).[9][20][21][22]

Awards and honours

Teichmann has won a number of awards. In 2010, she was awarded Colworth Medal from the Biochemical Society.[7][45] In 2012, Teichman was awarded the Francis Crick Medal and Lecture, membership of European Molecular Biology Organization (EMBO) and the Lister Prize from the Lister Institute of Preventive Medicine.[23] In 2015 she was awarded the Michael and Kate Bárány Award for young investigators by the Biophysical Society.[46]

References

  1. ↑ 1.0 1.1 1.2 "Sarah Amalia Teichmann PhD MA BA (Hons cantab) CV" (PDF). Laboratory of Molecular Biology. 2007. Archived from the original (PDF) on 2013-02-26.
  2. ↑ Sarah Teichmann's publications indexed by Google Scholar, a free service provided by Google
  3. ↑ 3.0 3.1 "People & Groups: Sarah Teichmann, Group Leader - Teichmann research group". EMBL-EBI. 2013. Archived from the original on 2013-04-03.
  4. ↑ Park, J; Teichmann, S. A.; Hubbard, T; Chothia, C (1997). "Intermediate sequences increase the detection of homology between sequences". Journal of Molecular Biology 273 (1): 349–54. doi:10.1006/jmbi.1997.1288. PMID 9367767.
  5. ↑ Teichmann, S. A.; Rison, S. C.; Thornton, J. M.; Riley, M; Gough, J; Chothia, C (2001). "The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli". Journal of Molecular Biology 311 (4): 693–708. doi:10.1006/jmbi.2001.4912. PMID 11518524.
  6. ↑ 6.0 6.1 Marx, V. (2014). "The Author File: Janet Thornton". Nature Methods 11 (2): 115. doi:10.1038/nmeth.2831.
  7. ↑ 7.0 7.1 "Honour and heirloom for Sarah Teichmann". Laboratory of Molecular Biology. 2012. Archived from the original on 2015-03-03.
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 8.10 Teichmann, Sarah (2015). "Alumni from Sarah Teichmann's Group". European Bioinformatics Institute. Archived from the original on 2015-02-20.
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 9.9 9.10 9.11 9.12 9.13 9.14 9.15 9.16 "Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany". Federation of European Biochemical Societies. 2015. Archived from the original on 2015-02-20.
  10. ↑ 10.0 10.1 10.2 Babu Mohan, Madan (2004). Evolution of transcriptional regulatory networks (PhD thesis). University of Cambridge.
  11. ↑ 11.0 11.1 Babu, M. M.; Luscombe, N. M.; Aravind, L; Gerstein, M; Teichmann, S. A. (2004). "Structure and evolution of transcriptional regulatory networks". Current Opinion in Structural Biology 14 (3): 283–91. doi:10.1016/j.sbi.2004.05.004. PMID 15193307.
  12. ↑ 12.0 12.1 Charoensawan, Varodom (2011). Evolution and dynamics of transcription factors and gene expression patterns (PhD thesis). University of Cambridge.
  13. ↑ 13.0 13.1 Charoensawan, Varodom (2008). Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood (PhD thesis). University of Cambridge.
  14. ↑ 14.0 14.1 Han, Jay (2007). Structure, function and evolution of protein-protein interactions (PhD thesis). University of Cambridge.
  15. ↑ 15.0 15.1 Kummerfeld, Sarah Kay (2006). Towards understanding the protein universe : genome-scale studies of evolution and gene regulation (PhD thesis). University of Cambridge.
  16. ↑ 16.0 16.1 Levy, Emmanuel Doram (2008). Classification, evolution, and assembly of protein complexes (PhD thesis). University of Cambridge.
  17. ↑ 17.0 17.1 Perica, Tina (2013). Evolutionary and structural dynamics of protein complexes (PhD thesis). University of Cambridge.
  18. ↑ 18.0 18.1 Su, Jing (2012). Computational prediction of regulatory elements (PhD thesis). University of Cambridge.
  19. ↑ Pereira-Leal, J. B.; Teichmann, S. A. (2005). "Novel specificities emerge by stepwise duplication of functional modules". Genome Research 15 (4): 552–9. doi:10.1101/gr.3102105. PMC 1074369. PMID 15805495.
  20. ↑ 20.0 20.1 Adryan, B; Teichmann, S. A. (2010). "The developmental expression dynamics of Drosophila melanogaster transcription factors". Genome Biology 11 (4): R40. doi:10.1186/gb-2010-11-4-r40. PMC 2884543. PMID 20384991.
  21. ↑ 21.0 21.1 Gsponer, J; Futschik, M. E.; Teichmann, S. A.; Babu, M. M. (2008). "Tight regulation of unstructured proteins: From transcript synthesis to protein degradation". Science 322 (5906): 1365–8. doi:10.1126/science.1163581. PMC 2803065. PMID 19039133.
  22. ↑ 22.0 22.1 Hebenstreit, D; Gu, M; Haider, S; Turner, D. J.; Liò, P; Teichmann, S. A. (2011). "EpiChIP: Gene-by-gene quantification of epigenetic modification levels". Nucleic Acids Research 39 (5): e27. doi:10.1093/nar/gkq1226. PMC 3061070. PMID 21131282.
  23. ↑ 23.0 23.1 "Dr Sarah Teichmann, EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute". Archived from the original on 2014-10-15.
  24. ↑ "Finding patterns in genes and proteins: decoding the logic of molecular interactions". Royal Society. 2012. Archived from the original on 2012-10-10.
  25. ↑ Finding patterns in genes and proteins: decoding the logic of molecular interactions on YouTube, Royal Society
  26. ↑ "Dr Sarah Teichmann - Wellcome Trust Sanger Institute". Wellcome Trust. Archived from the original on 2014-07-08.
  27. ↑ "Welcome to the Teichmann Group". Archived from the original on 2015-02-20.
  28. ↑ "Sarah Teichmann MRC LMB". Archived from the original on 2013-03-22.
  29. ↑ 29.0 29.1 "Job titles and duties at the University of Cambridge". University of Cambridge. Archived from the original on 2013-07-03.
  30. ↑ Chothia, C; Gough, J; Vogel, C; Teichmann, S. A. (2003). "Evolution of the protein repertoire". Science 300 (5626): 1701–3. doi:10.1126/science.1085371. PMID 12805536.
  31. ↑ Teichmann, Sarah Amalia (1999). Genome evolution : analysing proteomes with new methods (PhD thesis). University of Cambridge.
  32. ↑ Luscombe, N. M.; Babu, M. M.; Yu, H; Snyder, M; Teichmann, S. A.; Gerstein, M (2004). "Genomic analysis of regulatory network dynamics reveals large topological changes". Nature 431 (7006): 308–12. doi:10.1038/nature02782. PMID 15372033.
  33. ↑ List of publications from Microsoft Academic Search
  34. ↑ Sarah Teichmann from the ACM Portal
  35. ↑ Sarah Teichmann's publications indexed by the DBLP Bibliography Server at the University of Trier
  36. ↑ Sarah Teichmann's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  37. ↑ Sarah Teichmann publications from Europe PubMed Central
  38. ↑ Carninci, P; Kasukawa, T; Katayama, S; Gough, J; Frith, M. C.; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, V. B.; Brenner, S. E.; Batalov, S; Forrest, A. R.; Zavolan, M; Davis, M. J.; Wilming, L. G.; Aidinis, V; Allen, J. E.; Ambesi-Impiombato, A; Apweiler, R; Aturaliya, R. N.; Bailey, T. L.; Bansal, M; Baxter, L; Beisel, K. W.; Bersano, T et al. (2005). "The transcriptional landscape of the mammalian genome". Science 309 (5740): 1559–63. doi:10.1126/science.1112014. PMID 16141072.
  39. ↑ Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature 450 (7167): 203–18. doi:10.1038/nature06341. PMID 17994087.
  40. ↑ Wilson, D; Charoensawan, V; Kummerfeld, S. K.; Teichmann, S. A. (2008). "DBD--taxonomically broad transcription factor predictions: New content and functionality". Nucleic Acids Research 36 (Database issue): D88–92. doi:10.1093/nar/gkm964. PMC 2238844. PMID 18073188.
  41. ↑ Levy, E. D.; Teichmann, S (2013). "Structural, Evolutionary, and Assembly Principles of Protein Oligomerization". Oligomerization in Health and Disease. Progress in molecular biology and translational science. Progress in Molecular Biology and Translational Science 117. pp. 25–51. doi:10.1016/B978-0-12-386931-9.00002-7. ISBN 9780123869319. PMID 23663964.
  42. ↑ Perica, T; Kondo, Y; Tiwari, S. P.; McLaughlin, S. H.; Kemplen, K. R.; Zhang, X; Steward, A; Reuter, N; Clarke, J; Teichmann, S. A. (2014). "Evolution of oligomeric state through allosteric pathways that mimic ligand binding". Science 346 (6216): 1254346. doi:10.1126/science.1254346. PMC 4337988. PMID 25525255.
  43. ↑ "Teichmann group Research EMBL-EBI". European Bioinformatics Institute. 2013. Archived from the original on 2013-04-02.
  44. ↑ "UK Government research grants awarded to Sarah Teichmann". Research Councils UK. 2015. Archived from the original on 2015-03-03.
  45. ↑ "Women at Cambridge: Sarah Amalia Teichmann". University of Cambridge. Archived from the original on 2015-02-20.
  46. ↑ "Biophysical Society Names 2015 Award Recipients" (PDF). Biophysical Society. Archived from the original (PDF) on 2014-10-04.