Salubrinal

Systematic (IUPAC) name
3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Clinical data
Identifiers
CAS Registry Number	405060-95-9 Y
PubChem	CID 5717801
ChemSpider	4654442 N
ChEMBL	CHEMBL180127 N
Chemical data
Formula	C21H17Cl3N4OS
Molecular mass	479.81 [1][2]
SMILES C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
InChI InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+  N Key:LCOIAYJMPKXARU-VAWYXSNFSA-N  N
N (what is this?)  (verify)

Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes^[3][4][5] and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit,^[6] resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum.^[7] Salubrinal has putative therapeutic value due to its function,^[3][5] but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.^[8]

References