SYTL4

Synaptotagmin-like 4

PDB rendering based on 2csz.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2CSZ, 3FDW

Identifiers

SYTL4 ; SLP4

External IDs

OMIM: 300723 MGI: 1351606 HomoloGene: 8454 GeneCards: SYTL4 Gene

Gene ontology
Molecular function	• transporter activity • phospholipid binding • zinc ion binding • Rab GTPase binding • neurexin family protein binding
Cellular component	• nucleus • nucleolus • cytoplasm • endosome • centrosome • plasma membrane • synaptic vesicle • extrinsic component of membrane • secretory granule • transport vesicle membrane
Biological process	• intracellular protein transport • exocytosis • positive regulation of exocytosis • negative regulation of insulin secretion • positive regulation of protein secretion • multivesicular body sorting pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000102362

ENSMUSG00000031255

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
99.93 – 99.99 Mb

Chr X:
133.94 – 133.98 Mb

PubMed search

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.^[1]

References

↑ "Entrez Gene: SYTL4 synaptotagmin-like 4 (granuphilin-a)".

Further reading

Wang J, Takeuchi T, Yokota H, Izumi T (1999). "Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells.". J. Biol. Chem. 274 (40): 28542–8. doi:10.1074/jbc.274.40.28542. PMID 10497219.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
Yi Z, Yokota H, Torii S et al. (2002). "The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules.". Mol. Cell. Biol. 22 (6): 1858–67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063.
Zhao S, Torii S, Yokota-Hashimoto H et al. (2002). "Involvement of Rab27b in the regulated secretion of pituitary hormones.". Endocrinology 143 (5): 1817–24. doi:10.1210/en.143.5.1817. PMID 11956164.
Torii S, Zhao S, Yi Z et al. (2002). "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a.". Mol. Cell. Biol. 22 (15): 5518–26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244.
Fukuda M, Kanno E, Saegusa C et al. (2002). "Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.". J. Biol. Chem. 277 (42): 39673–8. doi:10.1074/jbc.M205349200. PMID 12176990.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ciufo LF, Barclay JW, Burgoyne RD, Morgan A (2005). "Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.". Mol. Biol. Cell 16 (2): 470–82. doi:10.1091/mbc.E04-08-0685. PMC 545880. PMID 15563604.
Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Plaisance V, Abderrahmani A, Perret-Menoud V et al. (2006). "MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells.". J. Biol. Chem. 281 (37): 26932–42. doi:10.1074/jbc.M601225200. PMID 16831872.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

2csz: Solution Structure of the RING domain of the Synaptotagmin-like protein 4