SYT13
| Synaptotagmin XIII | |||||||||||||
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 PDB rendering based on 1wfm. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SYT13 ; KIAA1427 | ||||||||||||
| External IDs | OMIM: 607716 MGI: 1933945 HomoloGene: 10823 GeneCards: SYT13 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 57586 | 80976 | |||||||||||
| Ensembl | ENSG00000019505 | ENSMUSG00000027220 | |||||||||||
| UniProt | Q7L8C5 | Q9EQT6 | |||||||||||
| RefSeq (mRNA) | NM_001247987 | NM_030725 | |||||||||||
| RefSeq (protein) | NP_001234916 | NP_109650 | |||||||||||
| Location (UCSC) | Chr 11: 45.26 – 45.31 Mb | Chr 2: 92.92 – 92.96 Mb | |||||||||||
| PubMed search | |||||||||||||
Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.[1][2]
SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins show type I membrane topology, with an extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include vesicular traffic, exocytosis, and secretion.[supplied by OMIM][2]
References
- ↑ Fukuda M, Mikoshiba K (Feb 2001). "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)". Biochem J 354 (Pt 2): 249–57. doi:10.1042/0264-6021:3540249. PMC 1221650. PMID 11171101.
- ↑ 2.0 2.1 "Entrez Gene: SYT13 synaptotagmin XIII".
Further reading
- Nagase T; Kikuno R; Ishikawa KI et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC; Wellenreuther R; Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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