SYNPO

Synaptopodin

Identifiers

SYNPO ; KIAA1029

External IDs

OMIM: 608155 MGI: 1099446 HomoloGene: 5274 GeneCards: SYNPO Gene

Gene ontology
Molecular function	• actin binding • protein binding
Cellular component	• stress fiber • cytoplasm • tight junction • postsynaptic density • actin cytoskeleton • dendritic spine • perikaryon • postsynaptic membrane
Biological process	• positive regulation of actin filament bundle assembly • regulation of stress fiber assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000171992

ENSMUSG00000043079

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
149.98 – 150.04 Mb

Chr 18:
60.59 – 60.66 Mb

PubMed search

Synaptopodin is a protein that in humans is encoded by the SYNPO gene.^[1]^[2]^[3]

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM]^[3]

Interactions

SYNPO has been shown to interact with MAGI1.^[4]

References

↑ Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W (February 1998). "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes". J Cell Biol 139 (1): 193–204. doi:10.1083/jcb.139.1.193. PMC 2139823. PMID 9314539.
↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
↑ 3.0 3.1 "Entrez Gene: SYNPO synaptopodin".
↑ Patrie, Kevin M; Drescher Andrew J; Welihinda Ajith; Mundel Peter; Margolis Ben (August 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. (United States) 277 (33): 30183–90. doi:10.1074/jbc.M203072200. ISSN 0021-9258. PMID 12042308.

Further reading

Adams MD; Kerlavage AR; Fleischmann RD et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Patrie KM; Drescher AJ; Welihinda A et al. (2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y; Yamashita R; Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
He JC; Husain M; Sunamoto M et al. (2004). "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways". J. Clin. Invest. 114 (5): 643–51. doi:10.1172/JCI200421004. PMC 514582. PMID 15343382.
Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rush J; Moritz A; Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Kremerskothen J; Plaas C; Kindler S et al. (2005). "Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein". J. Neurochem. 92 (3): 597–606. doi:10.1111/j.1471-4159.2004.02888.x. PMID 15659229.
Asanuma K; Kim K; Oh J et al. (2005). "Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner". J. Clin. Invest. 115 (5): 1188–98. doi:10.1172/JCI200523371. PMC 1070637. PMID 15841212.
Husain M; D'Agati VD; He JC et al. (2006). "HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN". AIDS 19 (17): 1975–80. doi:10.1097/01.aids.0000191918.42110.27. PMID 16260903.
Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Hirakawa M; Tsuruya K; Yotsueda H et al. (2006). "Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis". Life Sci. 79 (8): 757–63. doi:10.1016/j.lfs.2006.02.031. PMID 16564554.
Asanuma K; Yanagida-Asanuma E; Faul C et al. (2006). "Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling". Nat. Cell Biol. 8 (5): 485–91. doi:10.1038/ncb1400. PMID 16622418.
Olsen JV; Blagoev B; Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Garovic VD; Wagner SJ; Petrovic LM et al. (2007). "Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia". Nephrol. Dial. Transplant. 22 (4): 1136–43. doi:10.1093/ndt/gfl711. PMID 17255128.