SYBL1

Vesicle-associated membrane protein 7

PDB rendering based on 2dmw.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DMW

Identifiers

Symbols

VAMP7 ; SYBL1; TI-VAMP; TIVAMP; VAMP-7

External IDs

OMIM: 300053 MGI: 1096399 HomoloGene: 4121 GeneCards: VAMP7 Gene

Gene ontology
Molecular function	• protein binding • syntaxin binding
Cellular component	• cytoplasm • lysosomal membrane • endoplasmic reticulum membrane • Golgi apparatus • plasma membrane • integral component of membrane • cell junction • transport vesicle membrane • phagocytic vesicle membrane • SNARE complex • late endosome membrane • neuron projection • intracellular membrane-bounded organelle • apical part of cell • synapse • phagocytic vesicle • perinuclear region of cytoplasm • extracellular vesicular exosome
Biological process	• autophagic vacuole fusion • ER to Golgi vesicle-mediated transport • post-Golgi vesicle-mediated transport • vesicle fusion • phagocytosis, engulfment • endosome to lysosome transport • vesicle-mediated transport • calcium ion-dependent exocytosis • triglyceride transport • Golgi to plasma membrane protein transport • eosinophil degranulation • neutrophil degranulation • vesicle fusion with Golgi apparatus • membrane organization • regulation of protein targeting to vacuolar membrane
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
155.11 – 155.17 Mb

Chr GL456233.1:
0.01 – 0.04 Mb

PubMed search

Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene.^[1]^[2]^[3]

Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.^[3]

Interactions

SYBL1 has been shown to interact with SNAP23^[4]^[5] and AP3D1.^[4]

References

↑ D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R et al. (Jul 1996). "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. doi:10.1038/ng0696-227. PMID 8640232. CS1 maint: Date and year (link)
↑ Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M (Jul 2001). "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841. CS1 maint: Date and year (link)
↑ 3.0 3.1 "Entrez Gene: SYBL1 synaptobrevin-like 1".
↑ 4.0 4.1 Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V et al. (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575. CS1 maint: Date and year (link)
↑ Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M et al. (Jun 1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185. CS1 maint: Date and year (link)

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M et al. (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.
Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH (1999). "VAMP-7 mediates vesicular transport from endosomes to lysosomes". J. Cell Biol. 146 (4): 765–76. doi:10.1083/jcb.146.4.765. PMC 2156136. PMID 10459012.
Matarazzo MR, Cuccurese M, Strazzullo M, Vacca M, Curci A, Miano MG et al. (1999). "Human and mouse SYBL1 gene structure and expression". Gene 240 (1): 233–8. doi:10.1016/S0378-1119(99)00375-3. PMID 10564831.
Ciccodicola A, D'Esposito M, Esposito T, Gianfrancesco F, Migliaccio C, Miano MG et al. (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
Ward DM, Pevsner J, Scullion MA, Vaughn M, Kaplan J (2000). "Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages". Mol. Biol. Cell 11 (7): 2327–33. doi:10.1091/mbc.11.7.2327. PMC 14922. PMID 10888671.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC et al. (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915.
Müller DJ, Schulze TG, Jahnes E, Cichon S, Krauss H, Kesper K et al. (2002). "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder". Am. J. Med. Genet. 114 (1): 74–8. doi:10.1002/ajmg.10115. PMID 11840509. Vancouver style error (help)
Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J et al. (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335.
Matarazzo MR, De Bonis ML, Gregory RI, Vacca M, Hansen RS, Mercadante G et al. (2002). "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes". Hum. Mol. Genet. 11 (25): 3191–8. doi:10.1093/hmg/11.25.3191. PMID 12444103.
Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V et al. (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
Di Leva F, Ferrante MI, Demarchi F, Caravelli A, Matarazzo MR, Giacca M et al. (2004). "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements". J. Biol. Chem. 279 (9): 7734–9. doi:10.1074/jbc.M308140200. PMID 14672948.
Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW (2004). "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis". J. Biol. Chem. 279 (19): 20471–9. doi:10.1074/jbc.M400798200. PMID 14993220.

PDB gallery

2dmw: Solution structure of the LONGIN domain of Synaptobrevin-like protein 1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

SYBL1

Function

Interactions

References

Further reading