SUGT1
| SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | |||||||||||||
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 PDB rendering based on 1rl1. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SUGT1 ; SGT1 | ||||||||||||
| External IDs | OMIM: 604098 MGI: 1915205 HomoloGene: 4877 GeneCards: SUGT1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10910 | 67955 | |||||||||||
| Ensembl | ENSG00000165416 | ENSMUSG00000022024 | |||||||||||
| UniProt | Q9Y2Z0 | Q9CX34 | |||||||||||
| RefSeq (mRNA) | NM_001130912 | NM_026474 | |||||||||||
| RefSeq (protein) | NP_001124384 | NP_080750 | |||||||||||
| Location (UCSC) | Chr 13: 52.65 – 52.7 Mb | Chr 14: 79.59 – 79.63 Mb | |||||||||||
| PubMed search | |||||||||||||
Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.[1][2]
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.[2]
Interactions
SUGT1 has been shown to interact with S100A6.[3]
References
- ↑ Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (Aug 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Mol Cell 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
- ↑ 2.0 2.1 "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
- ↑ Nowotny, Marcin; Spiechowicz Magdalena; Jastrzebska Beata; Filipek Anna; Kitagawa Katsumi; Kuznicki Jacek (Jul 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. (United States) 278 (29): 26923–8. doi:10.1074/jbc.M211518200. ISSN 0021-9258. PMID 12746458.
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Nowotny M, Spiechowicz M, Jastrzebska B et al. (2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.". J. Biol. Chem. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
- Niikura Y, Kitagawa K (2004). "Identification of a novel splice variant: human SGT1B (SUGT1B).". DNA Seq. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID 15018354.
- Zou X, Ji C, Wang L et al. (2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1.". DNA Seq. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID 15346769.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (2007). "SGT1 is essential for Nod1 activation.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6764–9. doi:10.1073/pnas.0610926104. PMC 1871859. PMID 17420470.
- Spiechowicz M, Zylicz A, Bieganowski P et al. (2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6.". Biochem. Biophys. Res. Commun. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.
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