SUDS3

Suppressor of defective silencing 3 homolog (S. cerevisiae)
Identifiers
SymbolsSUDS3 ; SAP45; SDS3
External IDsOMIM: 608250 MGI: 1919204 HomoloGene: 15906 GeneCards: SUDS3 Gene
Orthologs
SpeciesHumanMouse
Entrez6442671954
EnsemblENSG00000111707ENSMUSG00000066900
UniProtQ9H7L9Q8BR65
RefSeq (mRNA)NM_022491NM_001122666
RefSeq (protein)NP_071936NP_001116138
Location (UCSC)Chr 12:
118.81 – 118.86 Mb
Chr 5:
117.09 – 117.12 Mb
PubMed search

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.[1][2]

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM][2]

Interactions

SUDS3 has been shown to interact with HDAC1,[1][3] Host cell factor C1,[4] SIN3B[1] and SIN3A.[1][3]

References

  1. 1.0 1.1 1.2 1.3 Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H Jr, Chen K, DePinho RA (Mar 2002). "Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex". Mol Cell Biol 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
  2. 2.0 2.1 "Entrez Gene: SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)".
  3. 3.0 3.1 Fleischer, Tracey C; Yun Ui Jeong; Ayer Donald E (May 2003). "Identification and Characterization of Three New Components of the mSin3A Corepressor Complex". Mol. Cell. Biol. (United States) 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. ISSN 0270-7306. PMC 164750. PMID 12724404.
  4. Wysocka, Joanna; Myers Michael P; Laherty Carol D; Eisenman Robert N; Herr Winship (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. (United States) 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026. PMID 12670868.

Further reading