STRN3

Striatin, calmodulin binding protein 3

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4N6J

Identifiers

STRN3 ; SG2NA

External IDs

OMIM: 614766 HomoloGene: 82078 GeneCards: STRN3 Gene

Gene ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • protein binding • calmodulin binding • protein complex binding • protein phosphatase 2A binding • armadillo repeat domain binding
Cellular component	• protein phosphatase type 2A complex • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • plasma membrane • dendrite • neuronal cell body • protein complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • response to estradiol • negative regulation of intracellular estrogen receptor signaling pathway • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000196792

ENSMUSG00000020954

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
31.36 – 31.5 Mb

Chr 12:
51.61 – 51.69 Mb

PubMed search

Striatin-3 is a protein that in humans is encoded by the STRN3 gene.^[1]^[2]^[3]

Interactions

STRN3 has been shown to interact with:

References

↑ Muro Y, Chan EK, Landberg G, Tan EM (Mar 1995). "A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells". Biochem. Biophys. Res. Commun. 207 (3): 1029–37. doi:10.1006/bbrc.1995.1288. PMID 7864889. CS1 maint: Date and year (link)
↑ Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS et al. (Mar 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496. CS1 maint: Date and year (link)
↑ "Entrez Gene: STRN3 striatin, calmodulin binding protein 3".
↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A et al. (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. CS1 maint: Date and year (link)
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

Landberg G, Tan EM (1994). "Characterization of a DNA-binding nuclear autoantigen mainly associated with S phase and G2 cells". Exp. Cell Res. 212 (2): 255–61. doi:10.1006/excr.1994.1141. PMID 7910562.
Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi:10.1074/jbc.M909782199. PMID 10748158.
Moreno CS, Lane WS, Pallas DC (2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". J. Biol. Chem. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. Vancouver style error (help)
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.