STK25

Serine/threonine kinase 25
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsSTK25 ; SOK1; YSK1
External IDsOMIM: 602255 MGI: 1891699 HomoloGene: 48428 IUPHAR: 2218 ChEMBL: 5552 GeneCards: STK25 Gene
EC number2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1049459041
EnsemblENSG00000115694ENSMUSG00000026277
UniProtO00506Q9Z2W1
RefSeq (mRNA)NM_001271977NM_021537
RefSeq (protein)NP_001258906NP_067512
Location (UCSC)Chr 2:
242.43 – 242.45 Mb
Chr 1:
93.62 – 93.64 Mb
PubMed search

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.[1][2][3][4]

Interactions

STK25 has been shown to interact with STRN,[5] PDCD10[6] and MOBKL3.[5]

References

  1. Pombo CM, Bonventre JV, Molnar A, Kyriakis J, Force T (Jan 1997). "Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway". EMBO J 15 (17): 4537–46. PMC 452183. PMID 8887545.
  2. Osada S, Izawa M, Saito R, Mizuno K, Suzuki A, Hirai S, Ohno S (Jun 1997). "YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways". Oncogene 14 (17): 2047–57. doi:10.1038/sj.onc.1201043. PMID 9160885.
  3. Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (Mar 2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J Cell Biol 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC 2172068. PMID 15037601.
  4. "Entrez Gene: STK25 serine/threonine kinase 25 (STE20 homolog, yeast)".
  5. 5.0 5.1 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  6. Rual JF, Venkatesan K, Hao T et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading