STK19
| Serine/threonine kinase 19 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | STK19 ; D6S60; D6S60E; G11; HLA-RP1; RP1 | ||||||||||||
| External IDs | OMIM: 604977 MGI: 1860085 HomoloGene: 10449 IUPHAR: 2216 GeneCards: STK19 Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8859 | 54402 | |||||||||||
| Ensembl | ENSG00000204344 | ENSMUSG00000061207 | |||||||||||
| UniProt | P49842 | Q9JHN8 | |||||||||||
| RefSeq (mRNA) | NM_004197 | NM_019442 | |||||||||||
| RefSeq (protein) | NP_004188 | NP_062315 | |||||||||||
| Location (UCSC) | Chr 6: 31.94 – 31.95 Mb | Chr 17: 34.82 – 34.84 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.[1][2][3]
This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.[3]
References
- ↑ Sargent CA, Anderson MJ, Hsieh SL, Kendall E, Gomez-Escobar N, Campbell RD (Jul 1994). "Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex". Hum Mol Genet 3 (3): 481–8. doi:10.1093/hmg/3.3.481. PMID 8012361.
- ↑ Gomez-Escobar N, Chou CF, Lin WW, Hsieh SL, Campbell RD (Dec 1998). "The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase". J Biol Chem 273 (47): 30954–60. doi:10.1074/jbc.273.47.30954. PMID 9812991.
- ↑ 3.0 3.1 "Entrez Gene: STK19 serine/threonine kinase 19".
Further reading
- Yu CY (1991). "The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene.". J. Immunol. 146 (3): 1057–66. PMID 1988494.
- Shen L, Wu LC, Sanlioglu S et al. (1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.". J. Biol. Chem. 269 (11): 8466–76. PMID 8132574.
- Ulgiati D, Townend DC, Christiansen FT et al. (1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype.". Immunogenetics 43 (4): 250–2. doi:10.1007/s002510050059. PMID 8575831.
- Yang Z, Shen L, Dangel AW et al. (1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.". Genomics 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Lehner B, Semple JI, Brown SE et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Wadle A, Mischo A, Henrich PP et al. (2005). "Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity.". Int. J. Cancer 117 (6): 896–904. doi:10.1002/ijc.21259. PMID 15986447.