STAT5A

Signal transducer and activator of transcription 5A

PDB rendering based on 1y1u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsSTAT5A ; MGF; STAT5
External IDsOMIM: 601511 MGI: 103036 HomoloGene: 20680 ChEMBL: 5403 GeneCards: STAT5A Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez677620850
EnsemblENSG00000126561ENSMUSG00000004043
UniProtP42229P42230
RefSeq (mRNA)NM_001288718NM_001164062
RefSeq (protein)NP_001275647NP_001157534
Location (UCSC)Chr 17:
40.44 – 40.46 Mb		Chr 11:
100.86 – 100.89 Mb
PubMed search

Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene.[1][2] STAT5A orthologs [3] have been identified in several placentals for which complete genome data are available.

Function

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.[4]

Interactions

STAT5A has been shown to interact with:

See also

References

  1. ↑ Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL (May 1995). "Identification and purification of human Stat proteins activated in response to interleukin-2". Immunity 2 (4): 321–9. doi:10.1016/1074-7613(95)90140-X. PMID 7719937.
  2. ↑ Lin JX, Mietz J, Modi WS, John S, Leonard WJ (July 1996). "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells". J. Biol. Chem. 271 (18): 10738–44. doi:10.1074/jbc.271.18.10738. PMID 8631883.
  3. ↑ "OrthoMaM phylogenetic marker: STAT5A coding sequence".
  4. ↑ "Entrez Gene: STAT5A signal transducer and activator of transcription 5A".
  5. ↑ Ota J, Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N et al. (November 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin". Biochem. Biophys. Res. Commun. 252 (3): 779–86. doi:10.1006/bbrc.1998.9445. PMID 9837784.
  6. ↑ 6.0 6.1 Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): 2005.0008. doi:10.1038/msb4100012. PMC 1681463. PMID 16729043.
  7. ↑ Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". J. Biol. Chem. 274 (24): 17209–18. doi:10.1074/jbc.274.24.17209. PMID 10358079.
  8. ↑ Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L et al. (November 2004). "The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone". J. Cell Biol. 167 (3): 469–78. doi:10.1083/jcb.200403155. PMC 2172499. PMID 15534001.
  9. ↑ Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle JN, Miura O (December 1996). "Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3". Blood 88 (12): 4415–25. PMID 8977232.
  10. ↑ 10.0 10.1 Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T et al. (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382.
  11. ↑ Barahmand-Pour F, Meinke A, Groner B, Decker T (May 1998). "Jak2-Stat5 interactions analyzed in yeast". J. Biol. Chem. 273 (20): 12567–75. doi:10.1074/jbc.273.20.12567. PMID 9575217.
  12. ↑ Pircher TJ, Petersen H, Gustafsson JA, Haldosén LA (April 1999). "Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a". Mol. Endocrinol. 13 (4): 555–65. doi:10.1210/mend.13.4.0263. PMID 10194762. Vancouver style error (help)
  13. ↑ Dinerstein-Cali H, Ferrag F, Kayser C, Kelly PA, Postel-Vinay M (August 2000). "Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins". Mol. Cell. Endocrinol. 166 (2): 89–99. doi:10.1016/S0303-7207(00)00277-X. PMID 10996427.
  14. ↑ Zhu M, John S, Berg M, Leonard WJ (January 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503.
  15. ↑ Yu CL, Jin YJ, Burakoff SJ (January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. 275 (1): 599–604. doi:10.1074/jbc.275.1.599. PMID 10617656.
  16. ↑ Chughtai N, Schimchowitsch S, Lebrun JJ, Ali S (August 2002). "Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells". J. Biol. Chem. 277 (34): 31107–14. doi:10.1074/jbc.M200156200. PMID 12060651.

Further reading

  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1-2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.
  • Buitenhuis M, Coffer PJ, Koenderman L (2004). "Signal transducer and activator of transcription 5 (STAT5)". Int. J. Biochem. Cell Biol. 36 (11): 2120–4. doi:10.1016/j.biocel.2003.11.008. PMID 15313458.