SSPO

SCO-spondin homolog (Bos taurus)

Identifiers

SSPO ; SCO-spondin

External IDs

MGI: 2674311 HomoloGene: 45453 GeneCards: SSPO Gene

Gene ontology
Molecular function	• peptidase inhibitor activity
Cellular component	• extracellular space
Biological process	• cell adhesion
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000197558

ENSMUSG00000029797

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
149.47 – 149.53 Mb

Chr 6:
48.45 – 48.5 Mb

PubMed search

SCO-spondin is a protein that in humans is encoded by the SSPO gene.^[1]^[2]^[3] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.^[4]

References

↑ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (Dec 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". J Cell Sci. 109. ( Pt 5): 1053–61. PMID 8743952.
↑ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (Nov 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217.
↑ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
↑ Gobron, S.; Creveaux, I.; Meiniel, R.; Didier, R.; Dastugue, B.; Meiniel, A. (1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience 88 (2): 655–664. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783.

Further reading

Meiniel A, Meiniel R, Gonçalves-Mendes N et al. (2004). "The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines.". Int. Rev. Cytol. 230: 1–39. doi:10.1016/S0074-7696(03)30001-4. PMID 14692680.
Meiniel O, Meiniel A (2007). "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals.". Brain Research Reviews 53 (2): 321–7. doi:10.1016/j.brainresrev.2006.09.007. PMID 17126404.
Nagase T, Ishikawa K, Miyajima N et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gonçalves-Mendes N, Simon-Chazottes D, Creveaux I et al. (2003). "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain.". Gene 312: 263–70. doi:10.1016/S0378-1119(03)00622-X. PMID 12909363.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gonçalves-Mendes N, Blanchon L, Meiniel A et al. (2004). "Placental expression of SCO-spondin during mouse and human development.". Gene Expr. Patterns 4 (3): 309–14. doi:10.1016/j.modgep.2003.10.004. PMID 15053980.
Cheng J, Kapranov P, Drenkow J et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.