SRPX2

Sushi-repeat containing protein, X-linked 2

Identifiers

SRPX2 ; BPP; CBPS; PMGX; RESDX; SRPUL

External IDs

OMIM: 300642 MGI: 1916042 HomoloGene: 8704 GeneCards: SRPX2 Gene

Gene ontology
Molecular function	• receptor binding • protein binding • hepatocyte growth factor binding • identical protein binding
Cellular component	• extracellular space • cytoplasm • cell surface • cell junction • excitatory synapse • synaptic membrane
Biological process	• angiogenesis • single organismal cell-cell adhesion • regulation of phosphorylation • cell motility • positive regulation of synapse assembly • positive regulation of cell migration involved in sprouting angiogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000102359

ENSMUSG00000031253

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
99.9 – 99.93 Mb

Chr X:
133.91 – 133.93 Mb

PubMed search

Sushi repeat-containing protein SRPX2 is a protein that in humans is encoded by the SRPX2 gene.^[1]^[2] Bioinformatics analysis suggests the SRPX2 protein is a peroxiredoxin. ^[3]

References

↑ Kurosawa H, Goi K, Inukai T, Inaba T, Chang KS, Shinjyo T, Rakestraw KM, Naeve CW, Look AT (Feb 1999). "Two candidate downstream target genes for E2A-HLF". Blood 93 (1): 321–32. PMID 9864177.
↑ "Entrez Gene: SRPX2 sushi-repeat-containing protein, X-linked 2".
↑ Pawłowski K; Muszewska A; Lenart A et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Further reading

Suzuki Y; Taira H; Tsunoda T et al. (2001). "Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites". EMBO Rep. 2 (5): 388–93. doi:10.1093/embo-reports/kve085. PMC 1083880. PMID 11375929.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y; Yamashita R; Shirota M et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT; Grafham DV; Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Otsuki T; Ota T; Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Roll P; Rudolf G; Pereira S et al. (2006). "SRPX2 mutations in disorders of language cortex and cognition". Hum. Mol. Genet. 15 (7): 1195–207. doi:10.1093/hmg/ddl035. PMID 16497722.
Royer B; Soares DC; Barlow PN et al. (2008). "Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas". BMC Genet. 8: 72. doi:10.1186/1471-2156-8-72. PMC 2151080. PMID 17942002.