SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

PDB rendering based on 2gnc.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2gnc

Identifiers

SRGAP3 ; ARHGAP14; MEGAP; SRGAP2; WRP

External IDs

OMIM: 606525 MGI: 2152938 HomoloGene: 56686 GeneCards: SRGAP3 Gene

Gene ontology
Molecular function	• GTPase activator activity • protein binding
Cellular component	• cytosol
Biological process	• small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000196220

ENSMUSG00000030257

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
9.02 – 9.4 Mb

Chr 6:
112.72 – 112.95 Mb

PubMed search

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.^[1]^[2]

References

↑ Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A 99 (18): 11754–9. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.
↑ "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

Further reading

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Ishikawa K, Nagase T, Nakajima D et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Hirosawa M, Nagase T, Ishikawa K et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Wong K, Ren XR, Huang YZ et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.". Cell 107 (2): 209–21. doi:10.1016/S0092-8674(01)00530-X. PMID 11672528.
Olave I, Wang W, Xue Y et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex.". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
Soderling SH, Binns KL, Wayman GA et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Yang Y, Marcello M, Endris V et al. (2006). "MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation.". Exp. Cell Res. 312 (12): 2379–93. doi:10.1016/j.yexcr.2006.04.001. PMID 16730001.

PDB gallery

2gnc: Crystal structure of srGAP1 SH3 domain in the slit-robo signaling pathway