SPRED3
| Sprouty-related, EVH1 domain containing 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SPRED3 ; Eve-3; spred-3 | ||||||||||
| External IDs | OMIM: 609293 MGI: 2142186 HomoloGene: 28061 GeneCards: SPRED3 Gene | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 399473 | 101809 | |||||||||
| Ensembl | ENSG00000267473 | ENSMUSG00000037239 | |||||||||
| UniProt | Q2MJR0 | Q6P6N5 | |||||||||
| RefSeq (mRNA) | NM_001039616 | NM_182927 | |||||||||
| RefSeq (protein) | NP_001035987 | NP_891557 | |||||||||
| Location (UCSC) | Chr 19: 38.88 – 38.89 Mb | Chr 7: 29.16 – 29.17 Mb | |||||||||
| PubMed search | |||||||||||
Sprouty-related, EVH1 domain-containing protein 3 also known as Spred-3 is a protein that in humans is encoded by the SPRED3 gene.[1]
Spred-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.[2][1]
References
- ↑ 1.0 1.1 "Entrez Gene: sprouty-related".
- ↑ Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". J. Biol. Chem. 279 (50): 52543–51. doi:10.1074/jbc.M405189200. PMID 15465815.
Further reading
- Kato R, Nonami A, Taketomi T, et al. (2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.". Biochem. Biophys. Res. Commun. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
- Mizoguchi M, Nutt CL, Louis DN (2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma.". Neurogenetics 5 (1): 81–2. doi:10.1007/s10048-003-0164-x. PMID 14618415.
- King JA, Corcoran NM, D'Abaco GM, et al. (2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling.". J. Hepatol. 44 (4): 758–67. doi:10.1016/j.jhep.2005.10.031. PMID 16478641.
- Lock P, I ST, Straffon AF, et al. (2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.". Biochem. Biophys. Res. Commun. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.