SPI1

Spi-1 proto-oncogene
PDB rendering based on 1pue.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1pue
Identifiers
Symbols	SPI1 ; OF; PU.1; SFPI1; SPI-1; SPI-A
External IDs	OMIM: 165170 MGI: 98282 HomoloGene: 2346 GeneCards: SPI1 Gene
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • sequence-specific DNA binding RNA polymerase II transcription factor activity • core promoter binding • RNA polymerase II transcription factor binding • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • RNA binding • protein binding • NFAT protein binding Cellular component • nuclear chromatin Biological process • negative regulation of transcription from RNA polymerase II promoter • lymphoid progenitor cell differentiation • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • lymphocyte differentiation • erythrocyte differentiation • macrophage differentiation • granulocyte differentiation • somatic stem cell maintenance • myeloid dendritic cell differentiation • histone H3 acetylation • hypermethylation of CpG island • negative regulation of MHC class II biosynthetic process • regulation of erythrocyte differentiation • negative regulation of gene expression, epigenetic • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • anatomical structure regression • negative regulation of histone H4 acetylation • apoptotic process involved in patterning of blood vessels Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6688	20375
Ensembl	ENSG00000066336	ENSMUSG00000002111
UniProt	P17947	P17433
RefSeq (mRNA)	NM_001080547	NM_011355
RefSeq (protein)	NP_001074016	NP_035485
Location (UCSC)	Chr 11: 47.38 – 47.4 Mb	Chr 2: 91.08 – 91.12 Mb
PubMed search

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.^[1]

Function

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

SPI1 has been shown to interact with:

• FUS,^[3]
• GATA2,^[4]
• IRF4,^[5][6] and
• NONO.^[7]

See also

• Spi-1 (PU.1) 5' UTR regulatory element

References

Further reading

External links

• FactorBook PU.1

PDB gallery 1pue: PU.1 ETS DOMAIN-DNA COMPLEX