SPEN

Spen family transcriptional repressor

PDB rendering based on 1ow1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsSPEN ; HIAA0929; MINT; RBM15C; SHARP
External IDsOMIM: 613484 MGI: 1891706 HomoloGene: 124461 GeneCards: SPEN Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2301356381
EnsemblENSG00000065526ENSMUSG00000040761
UniProtQ96T58Q62504
RefSeq (mRNA)NM_015001NM_019763
RefSeq (protein)NP_055816NP_062737
Location (UCSC)Chr 1:
16.17 – 16.27 Mb
Chr 4:
141.47 – 141.54 Mb
PubMed search

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.[1][2][3]

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.[3]

Interactions

SPEN has been shown to interact with HDAC1,[2] SRA1[2] and Nuclear receptor co-repressor 2.[2]

References

  1. Newberry EP, Latifi T, Towler DA (Sep 1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter". Biochemistry 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.
  2. 2.0 2.1 2.2 2.3 Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
  3. 3.0 3.1 "Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)".

Further reading