SOCS6

Suppressor of cytokine signaling 6

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2VIF

Identifiers

Symbols

SOCS6 ; CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4

External IDs

OMIM: 605118 MGI: 1924885 HomoloGene: 3120 GeneCards: SOCS6 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• immunological synapse • cytoplasm
Biological process	• defense response • JAK-STAT cascade • negative regulation of signal transduction • proteasomal protein catabolic process • protein ubiquitination • regulation of growth • negative regulation of T cell activation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 18:
67.96 – 68 Mb

Chr 18:
88.67 – 88.93 Mb

PubMed search

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.^[1]^[2]^[3]

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.^[3]

References

↑ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
↑ 3.0 3.1 "Entrez Gene: SOCS6 suppressor of cytokine signaling 6".

Kile BT, Schulman BA, Alexander WS et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Mooney RA, Senn J, Cameron S et al. (2001). "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.". J. Biol. Chem. 276 (28): 25889–93. doi:10.1074/jbc.M010579200. PMID 11342531.
Krebs DL, Uren RT, Metcalf D et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bayle J, Letard S, Frank R et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Bayle J, Lopez S, Iwaï K et al. (2006). "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.". FEBS Lett. 580 (11): 2609–14. doi:10.1016/j.febslet.2006.03.093. PMID 16643902.
Hwang MN, Ha TH, Park J et al. (2007). "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.". Biochem. Biophys. Res. Commun. 354 (1): 184–9. doi:10.1016/j.bbrc.2006.12.175. PMID 17210122.
Hwang MN, Min CH, Kim HS et al. (2007). "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels.". Biochem. Biophys. Res. Commun. 360 (2): 333–8. doi:10.1016/j.bbrc.2007.06.062. PMID 17603019.

JAK-STAT signaling pathway

Ligand

Cytokine

Cytokine receptor

Janus kinase

Adaptor proteins

STAT	STAT1 STAT2 STAT3 STAT4 STAT5 STAT6

PIAS	PIAS1 PIAS2 PIAS3 PIAS4

SOCS	1 2 3 4 5 6 7 CISH

IRF	IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

SOCS6

References

Further reading