SNX4
| Sorting nexin 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SNX4 ; ATG24B | ||||||||||||
| External IDs | OMIM: 605931 MGI: 1916400 HomoloGene: 36143 GeneCards: SNX4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8723 | 69150 | |||||||||||
| Ensembl | ENSG00000114520 | ENSMUSG00000022808 | |||||||||||
| UniProt | O95219 | Q91YJ2 | |||||||||||
| RefSeq (mRNA) | NM_003794 | NM_080557 | |||||||||||
| RefSeq (protein) | NP_003785 | NP_542124 | |||||||||||
| Location (UCSC) | Chr 3: 125.17 – 125.24 Mb | Chr 16: 33.25 – 33.3 Mb | |||||||||||
| PubMed search | |||||||||||||
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[1][2]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[2]
Interactions
SNX4 has been shown to interact with BIN1.[3]
References
- ↑ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. PMC 109309. PMID 9819414.
- ↑ 2.0 2.1 "Entrez Gene: SNX4 sorting nexin 4".
- ↑ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell. Sci. (England) 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.
Further reading
- Traer CJ, Rutherford AC, Palmer KJ et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.". Nat. Cell Biol. 9 (12): 1370–80. doi:10.1038/ncb1656. PMID 17994011.
- Skånland SS, Wälchli S, Utskarpen A et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.". Traffic 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. PMID 17319803.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Leprince C, Le Scolan E, Meunier B et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.". J. Cell. Sci. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. PMID 12668730.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Parks WT, Frank DB, Huff C et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
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