SNX13
| Sorting nexin 13 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SNX13 ; RGS-PX1 | ||||||||||||
| External IDs | OMIM: 606589 MGI: 2661416 HomoloGene: 41011 GeneCards: SNX13 Gene | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 23161 | 217463 | |||||||||||
| Ensembl | ENSG00000071189 | ENSMUSG00000020590 | |||||||||||
| UniProt | Q9Y5W8 | Q6PHS6 | |||||||||||
| RefSeq (mRNA) | NM_015132 | NM_001014973 | |||||||||||
| RefSeq (protein) | NP_055947 | NP_001014973 | |||||||||||
| Location (UCSC) | Chr 7: 17.83 – 17.98 Mb | Chr 12: 35.05 – 35.15 Mb | |||||||||||
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Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[1][2][3]
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[3]
References
- ↑ Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem J 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
- ↑ Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (Nov 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science 294 (5548): 1939–42. doi:10.1126/science.1064757. PMID 11729322.
- ↑ 3.0 3.1 "Entrez Gene: SNX13 sorting nexin 13".
Further reading
- Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
- Nagase T; Ishikawa K; Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region". Cytogenet. Genome Res. 97 (3–4): 167–70. doi:10.1159/000066618. PMID 12438708.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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