SNW1

SNW domain containing 1
Identifiers
Symbols	SNW1 ; Bx42; NCOA-62; PRPF45; Prp45; SKIIP; SKIP
External IDs	OMIM: 603055 HomoloGene: 56557 GeneCards: SNW1 Gene
Gene ontology Molecular function • transcription coactivator activity • transcription corepressor activity • Notch binding • protein binding • nuclear hormone receptor binding • vitamin D receptor binding • retinoic acid receptor binding • poly(A) RNA binding • SMAD binding Cellular component • chromatin • nucleus • nucleoplasm • spliceosomal complex • nucleolus • positive transcription elongation factor complex b • nuclear matrix • catalytic step 2 spliceosome • SMAD3-SMAD4 protein complex Biological process • negative regulation of transcription from RNA polymerase II promoter • mRNA splicing, via spliceosome • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • Notch signaling pathway • gene expression • viral process • positive regulation of transforming growth factor beta receptor signaling pathway • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation by host of viral transcription • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mRNA splicing, via spliceosome • retinoic acid receptor signaling pathway • regulation of retinoic acid receptor signaling pathway • positive regulation of neurogenesis • positive regulation of histone H3-K4 methylation • regulation of vitamin D receptor signaling pathway • positive regulation of vitamin D receptor signaling pathway • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22938	66354
Ensembl	ENSG00000100603	ENSMUSG00000021039
UniProt	Q13573	Q9CSN1
RefSeq (mRNA)	NM_012245	NM_025507
RefSeq (protein)	NP_036377	NP_079783
Location (UCSC)	Chr 14: 78.18 – 78.23 Mb	Chr 12: 87.45 – 87.47 Mb
PubMed search

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.^[1][2][3]

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.^[3]

Interactions

SNW1 has been shown to interact with Histone deacetylase 2,^[4] SKI protein,^[5][6][7] Retinoblastoma protein,^[8] PABPN1,^[9] CIR,^[4] RBPJ,^[4][10] Nuclear receptor coactivator 1,^[11] Nuclear receptor co-repressor 2,^[4][10] Calcitriol receptor,^[2][11] Mothers against decapentaplegic homolog 3,^[7] NOTCH1^[10][12] and Mothers against decapentaplegic homolog 2.^[7]

References

Further reading