SNF1LK2
| Salt-inducible kinase 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SIK2 ; LOH11CR1I; QIK; SNF1LK2 | ||||||||||||
| External IDs | OMIM: 608973 MGI: 2445031 HomoloGene: 22875 IUPHAR: 2198 ChEMBL: 5699 GeneCards: SIK2 Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23235 | 235344 | |||||||||||
| Ensembl | ENSG00000170145 | ENSMUSG00000037112 | |||||||||||
| UniProt | Q9H0K1 | Q8CFH6 | |||||||||||
| RefSeq (mRNA) | NM_015191 | NM_178710 | |||||||||||
| RefSeq (protein) | NP_056006 | NP_848825 | |||||||||||
| Location (UCSC) | Chr 11: 111.47 – 111.6 Mb | Chr 9: 50.89 – 51.01 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.[1][2]
Interactions
SNF1LK2 has been shown to interact with CRTC2.[3]
References
- ↑ Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.
- ↑ "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
- ↑ Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S et al. (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A et al. (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W et al. (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T et al. (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2". The Journal of Biological Chemistry 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
- Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats". International Journal of Oncology 23 (5): 1471–6. doi:10.3892/ijo.23.5.1471. PMID 14532992.
- Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J et al. (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
- Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S et al. (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N et al. (Nov 2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm". European Journal of Biochemistry / FEBS 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.