SNAG1
| Sorting nexin 18 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SNX18 ; SH3PX2; SH3PXD3B; SNAG1 | ||||||||||||
| External IDs | MGI: 2137642 HomoloGene: 14164 GeneCards: SNX18 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 112574 | 170625 | |||||||||||
| Ensembl | ENSG00000178996 | ENSMUSG00000042364 | |||||||||||
| UniProt | Q96RF0 | Q91ZR2 | |||||||||||
| RefSeq (mRNA) | NM_001102575 | NM_130796 | |||||||||||
| RefSeq (protein) | NP_001096045 | NP_570614 | |||||||||||
| Location (UCSC) | Chr 5: 53.81 – 53.84 Mb | Chr 13: 113.59 – 113.62 Mb | |||||||||||
| PubMed search | |||||||||||||
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.[1][2][3]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.[3]
References
- ↑ Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta 1761 (8): 878–96. doi:10.1016/j.bbalip.2006.04.011. PMID 16782399.
- ↑ Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett 581 (23): 4455–62. doi:10.1016/j.febslet.2007.08.025. PMID 17761170.
- ↑ 3.0 3.1 "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1".
Further reading
- Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
- Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
- Ozyildirim AM, Wistow GJ, Gao J et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. doi:10.1167/iovs.04-1380. PMID 15851553.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Teasdale RD, Loci D, Houghton F et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
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