SMYD4

SET and MYND domain containing 4
Identifiers
SymbolsSMYD4 ; ZMYND21
External IDsMGI: 2442796 HomoloGene: 35098 GeneCards: SMYD4 Gene
Orthologs
SpeciesHumanMouse
Entrez114826319822
EnsemblENSG00000186532ENSMUSG00000018809
UniProtQ8IYR2Q8BTK5
RefSeq (mRNA)NM_052928NM_001102611
RefSeq (protein)NP_443160NP_001096081
Location (UCSC)Chr 17:
1.68 – 1.73 Mb		Chr 11:
75.35 – 75.41 Mb
PubMed search

SET and MYND domain-containing protein 4 is a protein that in humans is encoded by the SMYD4 gene.[1][2]

Model organisms

Model organisms have been used in the study of SMYD4 function. A conditional knockout mouse line, called Smyd4tm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty six tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.[5]

References

  1. ↑ Nagase T, Kikuno R, Ohara O (Sep 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
  2. ↑ "Entrez Gene: SMYD4 SET and MYND domain containing 4".
  3. ↑ "Salmonella infection data for Smyd4". Wellcome Trust Sanger Institute.
  4. ↑ "Citrobacter infection data for Smyd4". Wellcome Trust Sanger Institute.
  5. ↑ 5.0 5.1 5.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ↑ "International Knockout Mouse Consortium".
  8. ↑ "Mouse Genome Informatics".
  9. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading