SMEK2
| SMEK homolog 2, suppressor of mek1 (Dictyostelium) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SMEK2 ; FLFL2; PP4R3B; PSY2; smk1 | ||||||||||||
| External IDs | OMIM: 610352 MGI: 2144474 HomoloGene: 68886 GeneCards: SMEK2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 57223 | 104570 | |||||||||||
| Ensembl | ENSG00000138041 | ENSMUSG00000020463 | |||||||||||
| UniProt | Q5MIZ7 | Q922R5 | |||||||||||
| RefSeq (mRNA) | NM_001122964 | NM_134034 | |||||||||||
| RefSeq (protein) | NP_001116436 | NP_598795 | |||||||||||
| Location (UCSC) | Chr 2: 55.77 – 55.85 Mb | Chr 11: 29.17 – 29.22 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 4 regulatory subunit 3B is an enzyme that in humans is encoded by the SMEK2 gene.[1][2][3]
Interactions
SMEK2 has been shown to interact with PPP4C.[4][5][1]
References
- ↑ 1.0 1.1 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol Cell Proteomics 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
- ↑ Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J (Jul 2008). "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication". Mol Cell 31 (1): 33–46. doi:10.1016/j.molcel.2008.05.016. PMC 3242369. PMID 18614045.
- ↑ "Entrez Gene: SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)".
- ↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- ↑ Chen, Ginny I; Tisayakorn Sally, Jorgensen Claus, D'Ambrosio Lisa M, Goudreault Marilyn, Gingras Anne-Claude (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". J. Biol. Chem. (United States) 283 (43): 29273–84. doi:10.1074/jbc.M803443200. ISSN 0021-9258. PMC 2662017. PMID 18715871.
Further reading
- Nagase T, Kikuno R, Ishikawa KI et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kittler R, Putz G, Pelletier L et al. (2005). "An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.". Nature 432 (7020): 1036–40. doi:10.1038/nature03159. PMID 15616564.
- Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Mendoza MC, Du F, Iranfar N et al. (2005). "Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.". Mol. Cell. Biol. 25 (17): 7839–53. doi:10.1128/MCB.25.17.7839-7853.2005. PMC 1190274. PMID 16107728.
- Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.